Huhti E, Poukkula A, Lilja M
Department of Medicine, University Central Hospital, Oulu, Finland.
Br J Dis Chest. 1987 Oct;81(4):381-90. doi: 10.1016/0007-0971(87)90187-2.
One hundred and ninety-nine cases of sarcoidosis were diagnosed from July 1970 to December 1976 in a defined geographical area in northern Finland. At the follow-up examination at least 5 years later (range 5-12 years) a chest röntgenogram was obtained from 179 patients (90%) and lung function tests were performed by 169 patients (85%). A normal röntgenogram was achieved by 94 of the 113 patients with stage I sarcoidosis (83%), and by 36 of the 62 patients with stage II (58%). Two patients in the former group (2%) and 14 in the latter (23%) had progressed to the fibrotic stage III, but the fibrosis was usually slight. FEV1 and FVC had increased during the follow-up period, DCO showing the largest number of abnormal results in the final examination. Lung function largely normalized with a normal röntgenogram, whereas the functional outcome was worst where fibrosis had developed. Only two patients had been granted a disability pension because of sarcoidosis. Six patients had died, but none of sarcoidosis. The results show a favourable prognosis for sarcoidosis in this comprehensive series of patients.
1970年7月至1976年12月期间，在芬兰北部一个特定地理区域诊断出199例结节病患者。至少5年后（5 - 12年）进行随访检查时，179名患者（90%）进行了胸部X光检查，169名患者（85%）进行了肺功能测试。113例I期结节病患者中有94例（83%）X光检查结果正常，62例II期患者中有36例（58%）结果正常。前一组中有2例患者（2%），后一组中有14例患者（23%）进展为纤维化III期，但纤维化通常较轻。随访期间FEV1和FVC有所增加，最终检查中DCO异常结果数量最多。X光检查结果正常时肺功能基本恢复正常，而出现纤维化时功能预后最差。只有2例患者因结节病获得了残疾抚恤金。6例患者死亡，但均非死于结节病。结果表明，在这一综合系列患者中，结节病预后良好。
