Fong C N, Atwood H L, Jeejeebhoy K N, Charlton M P
Department of Physiology, University of Toronto, Ont., Canada.
Can J Physiol Pharmacol. 1987 Nov;65(11):2188-90. doi: 10.1139/y87-345.
The effects of malnutrition on intracellular K+ activity, (alpha K)i, and membrane potential, Em, were measured by means of double-barrelled K+-selective microlectrodes in the soleus and gastrocnemius muscles of the rat. (alpha K)i and Em were measured in vivo in normal anaesthetized animals and in rats subjected to one of two diet restrictions: a 2-day fast or a long-term hypocaloric diet. In the soleus muscle, (alpha K)i fell by similar amounts in both 2-day fasted and long-term hypocalorically fed rats, while Em depolarized significantly only in hypocalorically fed rats. In the gastrocnemius muscle, neither the 2-day fast nor the hypocaloric diet affected (alpha K)i or Em. It is suggested that the selective loss of K+ from the soleus muscle may be related to its activity pattern.
通过双管钾离子选择性微电极测量了营养不良对大鼠比目鱼肌和腓肠肌细胞内钾离子活性（αK）i和膜电位Em的影响。在正常麻醉动物以及接受两种饮食限制之一的大鼠体内测量了αK）i和Em：2天禁食或长期低热量饮食。在比目鱼肌中，2天禁食和长期低热量喂养的大鼠的αK）i下降幅度相似，而Em仅在低热量喂养的大鼠中显著去极化。在腓肠肌中，2天禁食和低热量饮食均未影响αK）i或Em。有人提出，比目鱼肌中钾离子的选择性流失可能与其活动模式有关。
