Har-Gil Eden, Heled Ayala, Dixon Marjorie, Ahamed Abdul Munaf Sultan, Bentov Yaakov
Health Sciences - Wilfrid Laurier University, Waterloo, ON, Canada.
Health Sciences - McGill University, Montreal, QC, Canada.
J Cannabis Res. 2021 Sep 7;3(1):42. doi: 10.1186/s42238-021-00099-5.
The effects of cannabis use on male and female reproduction have been the focus of scientific research for decades. Although initial studies raised concerns, more recent studies were reassuring. Considering the recent legalization of recreational use of cannabis in Canada, we sought to analyze IVF outcomes among users and non-users in a single IVF center.
This is a retrospective cohort study from a single IVF center assessing IVF outcomes among male-female, non-donor IVF patients that are either cannabis users or non-users. We analyzed the ongoing pregnancy rate as well as oocyte yield, fertilization rate, peak serum estradiol, sperm, and embryo quality. We used the Mann-Whitney test, chi-square test, and Kruskal-Wallis tests where appropriate.
Overall, the study included 722 patients of which 68 (9.4%) were cannabis users, most defined as light users. The results of the study show similar implantation rate (40.74% vs. 41.13%) and ongoing pregnancy rate (35.2% vs. 29.1%) between the users and non-users, respectively. No significant difference between users and non-users in any of the other analyzed outcomes could be detected.
The results may provide some reassurance for the lack of any demonstrable detrimental effects of cannabis consumption on IVF outcomes. This study was limited by its retrospective nature, self-reporting of cannabis use, and a small user sample size. A larger prospective study is needed to validate its findings.
几十年来，大麻使用对男性和女性生殖的影响一直是科学研究的重点。尽管最初的研究引发了担忧，但最近的研究结果令人安心。鉴于加拿大近期将娱乐性大麻使用合法化，我们试图分析一家试管婴儿中心内大麻使用者和非使用者的试管婴儿治疗结果。
这是一项来自单一试管婴儿中心的回顾性队列研究，评估男性 - 女性、非供体试管婴儿患者（分为大麻使用者和非使用者）的试管婴儿治疗结果。我们分析了持续妊娠率以及卵母细胞产量、受精率、血清雌二醇峰值、精子和胚胎质量。在适当情况下，我们使用了曼 - 惠特尼检验、卡方检验和克鲁斯卡尔 - 沃利斯检验。
总体而言，该研究纳入了722名患者，其中68名（9.4%）为大麻使用者，大多数被定义为轻度使用者。研究结果显示，使用者和非使用者之间的着床率（分别为40.74%对41.13%）和持续妊娠率（分别为35.2%对29.1%）相似。在其他任何分析结果中，未检测到使用者和非使用者之间存在显著差异。
该结果可能为大麻消费对试管婴儿治疗结果没有任何明显有害影响提供了一些慰藉。本研究受到其回顾性性质、大麻使用情况的自我报告以及使用者样本量小的限制。需要进行更大规模的前瞻性研究来验证其结果。
