冻融胚胎移植后足月单胎儿的生长与新鲜胚胎移植后足月单胎儿的生长比较。

Childhood growth of term singletons born after frozen compared with fresh embryo transfer.

机构信息

Department of Obstetrics and Gynaecology, Oulu University Hospital, PL 23, Oulu 90029 OYS, Finland; Medical Research Center, PEDEGO Research Unit, University of Oulu, Oulu, Finland.

出版信息

Reprod Biomed Online. 2021 Oct;43(4):719-726. doi: 10.1016/j.rbmo.2021.08.002. Epub 2021 Aug 9.

DOI:10.1016/j.rbmo.2021.08.002

PMID:34493461

Abstract

RESEARCH QUESTION

Is the growth of term singletons born after frozen embryo transfer (FET) comparable to those born after fresh embryo transfer and natural conception up to 5 years of age?

DESIGN

Observational cohort study in an academic medical centre and municipal child health clinics with repeated measurements carried out by medical professionals. Term singletons born after FET (n = 110) and fresh embryo transfer (n = 181) and their matched natural conception controls (n = 543) born in Oulu, Northern Finland, were included. Mean weights, lengths, heights and head circumferences at the ages of 4, 8 and 18 months and 3 and 5 years were compared. At 3 and 5 years, body mass indices were compared.

RESULTS

Childhood growth did not differ between term singletons born after FET, fresh embryo transfer and natural conception, correcting for exact age at measurement and adjusting for maternal body mass index and paternal height.

CONCLUSIONS

Similar growth between children born after FET, fresh embryo transfer and natural conception offers reassurance of the safety and feasibility of the steadily increasing use of embryo cryopreservation in assisted reproduction.

摘要

研究问题

冷冻胚胎移植（FET）后足月单胎的生长速度是否与新鲜胚胎移植和自然受孕后至 5 岁的生长速度相当？

设计

在学术医疗中心和市立儿童健康诊所进行的观察性队列研究，由医疗专业人员进行重复测量。纳入在芬兰北部奥卢出生的 FET 后（n=110）和新鲜胚胎移植后（n=181）足月单胎及其匹配的自然受孕对照组（n=543）。比较 4、8 和 18 个月及 3 和 5 岁时的平均体重、长度、身高和头围。在 3 岁和 5 岁时，比较体重指数。