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肝结节病类似于原发性硬化性胆管炎。

Hepatic sarcoidosis resembling primary sclerosing cholangitis.

机构信息

Internal Medicine, Montefiore Medical Center, Bronx, New York, USA

Internal Medicine, St. Barnabas Hospital, Bronx, NY, USA.

出版信息

BMJ Case Rep. 2021 Sep 7;14(9):e243492. doi: 10.1136/bcr-2021-243492.

DOI:10.1136/bcr-2021-243492
PMID:34493554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8424844/
Abstract

We report the case of a 29-year-old man who presented with progressive weight loss, night sweats, abdominal pain and pruritus who was found to have obstructive jaundice and cholestatic pattern of liver injury on laboratory workup. Though findings on magnetic resonance cholangiopancreatography were initially concerning primary sclerosing cholangitis, he was ultimately diagnosed with biliary sarcoidosis after a liver biopsy. This case brings attention to the rare phenomenon of hepatic sarcoidosis causing hyperbilirubinemia and highlights the importance of reaching the correct diagnosis early, as the patient's symptoms improved after initiation of steroids.

摘要

我们报告了一例 29 岁男性,因进行性体重减轻、盗汗、腹痛和瘙痒就诊,实验室检查发现阻塞性黄疸和胆汁淤积性肝损伤。尽管磁共振胰胆管成像的结果最初提示原发性硬化性胆管炎,但在进行肝活检后,最终诊断为胆管肉瘤病。该病例引起了人们对肝肉瘤病导致高胆红素血症这一罕见现象的关注,并强调了早期做出正确诊断的重要性,因为患者在开始使用类固醇后症状有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/984f/8424844/452a8b746afe/bcr-2021-243492f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/984f/8424844/85738b4a2822/bcr-2021-243492f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/984f/8424844/452a8b746afe/bcr-2021-243492f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/984f/8424844/85738b4a2822/bcr-2021-243492f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/984f/8424844/452a8b746afe/bcr-2021-243492f02.jpg

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Cirrhosis due to hepatic sarcoidosis: A rare presentation.肝结节病所致肝硬化:一种罕见的表现。
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Secondary sclerosing cholangitis and IgG4-sclerosing cholangitis - A review of cholangiographic and ultrasound imaging.继发性硬化性胆管炎和IgG4相关性硬化性胆管炎——胆管造影和超声成像综述

本文引用的文献

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Extrapulmonary sarcoidosis primarily presenting as cholestatic liver disease.主要表现为胆汁淤积性肝病的肺外结节病。
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2
Hepatic Sarcoidosis: Natural History and Management Implications.肝结节病:自然史及管理意义
Front Med (Lausanne). 2019 Oct 30;6:232. doi: 10.3389/fmed.2019.00232. eCollection 2019.
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Sarcoidosis of the Intra- and Extrahepatic Bile Ducts with Concomitant Cholangitis in a Patient with Ulcerative Colitis.一名溃疡性结肠炎患者合并肝内外胆管结节病及胆管炎
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Clinical Characteristics and Outcome of Hepatic Sarcoidosis: A Population-Based Study 1976-2013.肝结节病的临床特征与转归:一项基于人群的1976 - 2013年研究
Am J Gastroenterol. 2017 Oct;112(10):1556-1563. doi: 10.1038/ajg.2017.231. Epub 2017 Sep 5.
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Ann Am Thorac Soc. 2016 Aug;13(8):1244-52. doi: 10.1513/AnnalsATS.201511-760OC.
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[Budd-Chiari syndrome: a rare complication of hepatic sarcoidosis (about one case)].布加综合征:肝结节病的一种罕见并发症(约1例)
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Lung. 2016 Feb;194(1):91-5. doi: 10.1007/s00408-015-9826-3. Epub 2015 Nov 13.