Raman A, Christou M, Gorrod J W
Chelsea Department of Pharmacy, King's College London, University of London, UK.
Eur J Drug Metab Pharmacokinet. 1987 Oct-Dec;12(4):279-83. doi: 10.1007/BF03189913.
The possible role of hydroxylamine and imine intermediates in the metabolism of amphetamine and related primary amines is discussed. The inherent instability of imines, has hitherto precluded the recognition of these compounds as metabolites of primary amines. During studies on the metabolism of o-methylbenzhydrylamine using washed hepatic microsomes from a number of mammalian species, the formation of o-methylbenzophenoneimine as a metabolite was observed. This metabolite was identified by preparative thin layer chromatography followed by gas-chromatography combined with mass spectrometry.
本文讨论了羟胺和亚胺中间体在苯丙胺及相关伯胺代谢过程中可能发挥的作用。亚胺固有的不稳定性，使得这些化合物迄今未被视作伯胺的代谢产物。在利用多种哺乳动物的洗涤肝微粒体对邻甲基二苯甲胺代谢进行研究的过程中，观察到了作为代谢产物的邻甲基二苯甲酮亚胺的形成。该代谢产物通过制备型薄层色谱法，随后结合气相色谱-质谱联用技术进行鉴定。
