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[Study of the phytoiatric antifungal activity of derivatives of 2- and 4-aminophenylthioacetonitrile and ethyl 4-aminophenylthioacetate].

作者信息

Carmellino M L, Massolini G

机构信息

Dipartimento di Chimica Farmaceutica, Università degli Studi di Pavia.

出版信息

Farmaco Sci. 1987 Dec;42(12):979-86.

PMID:3449396
Abstract

Some N-acyl and N-carbamoyl-derivatives of 2-, of 4-amino-phenylthioacetonitrile and of ethyl 4-aminophenylthioacetate, and also some N-thiocarbamoylderivatives of the latter were prepared in order to test their antimycotic activity against representative plant parasites. The substances, (I-XXVI), mostly unknown, were subjected to in vitro and in vivo tests (in preventive phase). Some of the compounds studied, especially the 2-aminophenylthioacetonitrilic derivatives, showed in the in vivo tests interesting activity and good specificy against P. viticola.

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