Bedossa P, Languille O, Lemaigre G, Martin E
Laboratoire d'Anatomie Pathologique, Hôpital Antoine-Béclère, Clamart.
Gastroenterol Clin Biol. 1987 Dec;11(12):869-73.
Forty-three solitary hyperplastic polyps removed from the colon or the rectum (HPC) were examined under light microscopy. A histochemical and immunohistochemical study was undertaken in order to evaluate semiquantitatively the nature and the distribution of epithelial mucins and the secretion of carcinoembryonic antigen (CEA). Ten HPC had a peculiar morphologic pattern (four with regenerative dysplasia and six with adenomatous foci). CEA secretion was always increased (37 per cent of cases) or highly increased (63 per cent of cases) with respect to the normal colonic mucosa. The nature and distribution of the secreted acid mucins were modified: sulfomucin was equal (25 per cent of cases) or higher (75 per cent of cases) than that in normal rectal or sigmoid colonic mucosae; sialomucin was strongly decreased in 91 per cent of cases. Some of these functional changes (CEA) are also observed in neoplastic lesions. These findings are not in accord with the hypothesis that hyperplastic polyp is a simple hyperplasia of the mucosal epithelium and suggest a disorder in cellular differentiation, particularly for the larger polyps.
对从结肠或直肠切除的43个孤立性增生性息肉（HPC）进行了光学显微镜检查。进行了组织化学和免疫组织化学研究，以便半定量评估上皮粘蛋白的性质和分布以及癌胚抗原（CEA）的分泌情况。10个HPC具有特殊的形态学模式（4个有再生性发育异常，6个有腺瘤性病灶）。与正常结肠黏膜相比，CEA分泌总是增加（37%的病例）或高度增加（63%的病例）。分泌的酸性粘蛋白的性质和分布发生了改变：硫粘蛋白与正常直肠或乙状结肠黏膜中的相等（25%的病例）或更高（75%的病例）；91%的病例中涎粘蛋白显著减少。在肿瘤性病变中也观察到了其中一些功能变化（CEA）。这些发现与增生性息肉是黏膜上皮单纯增生的假说不一致，并提示细胞分化存在紊乱，尤其是较大的息肉。
