miRNA-375：潜在的癌症抑制因子和治疗药物。

MicroRNA-375: potential cancer suppressor and therapeutic drug.

机构信息

Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin 130062, P.R. China.

The Eye Center in the Second Hospital of Jilin University, Ziqiang Street 218#, Nanguan District, Changchun City 130041, Jilin Province, China.

出版信息

Biosci Rep. 2021 Sep 30;41(9). doi: 10.1042/BSR20211494.

DOI:10.1042/BSR20211494

PMID:34494089

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8458691/

Abstract

MiR-375 is a conserved noncoding RNA that is known to be involved in tumor cell proliferation, migration, and drug resistance. Previous studies have shown that miR-375 affects the epithelial-mesenchymal transition (EMT) of human tumor cells via some key transcription factors, such as Yes-associated protein 1 (YAP1), Specificity protein 1 (SP1) and signaling pathways (Wnt signaling pathway, nuclear factor κB (NF-κB) pathway and transforming growth factor β (TGF-β) signaling pathway) and is vital for the development of cancer. Additionally, recent studies have identified microRNA (miRNA) delivery system carriers for improved in vivo transportation of miR-375 to specific sites. Here, we discussed the role of miR-375 in different types of cancers, as well as molecular mechanisms, and analyzed the potential of miR-375 as a molecular biomarker and therapeutic target to improve the efficiency of clinical diagnosis of cancer.

摘要

miR-375 是一种保守的非编码 RNA，已知参与肿瘤细胞的增殖、迁移和耐药性。先前的研究表明，miR-375 通过一些关键转录因子（如 Yes 相关蛋白 1（YAP1）、特异性蛋白 1（SP1）和信号通路（Wnt 信号通路、核因子 κB（NF-κB）通路和转化生长因子 β（TGF-β）信号通路）影响人肿瘤细胞的上皮-间充质转化（EMT），对癌症的发展至关重要。此外，最近的研究已经确定了 microRNA（miRNA）传递系统载体，以改善 miR-375 在体内向特定部位的运输。在这里，我们讨论了 miR-375 在不同类型癌症中的作用以及分子机制，并分析了 miR-375 作为分子生物标志物和治疗靶点的潜力，以提高癌症临床诊断的效率。