Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin 130062, P.R. China.
The Eye Center in the Second Hospital of Jilin University, Ziqiang Street 218#, Nanguan District, Changchun City 130041, Jilin Province, China.
Biosci Rep. 2021 Sep 30;41(9). doi: 10.1042/BSR20211494.
MiR-375 is a conserved noncoding RNA that is known to be involved in tumor cell proliferation, migration, and drug resistance. Previous studies have shown that miR-375 affects the epithelial-mesenchymal transition (EMT) of human tumor cells via some key transcription factors, such as Yes-associated protein 1 (YAP1), Specificity protein 1 (SP1) and signaling pathways (Wnt signaling pathway, nuclear factor κB (NF-κB) pathway and transforming growth factor β (TGF-β) signaling pathway) and is vital for the development of cancer. Additionally, recent studies have identified microRNA (miRNA) delivery system carriers for improved in vivo transportation of miR-375 to specific sites. Here, we discussed the role of miR-375 in different types of cancers, as well as molecular mechanisms, and analyzed the potential of miR-375 as a molecular biomarker and therapeutic target to improve the efficiency of clinical diagnosis of cancer.
miR-375 是一种保守的非编码 RNA，已知参与肿瘤细胞的增殖、迁移和耐药性。先前的研究表明，miR-375 通过一些关键转录因子（如 Yes 相关蛋白 1（YAP1）、特异性蛋白 1（SP1）和信号通路（Wnt 信号通路、核因子 κB（NF-κB）通路和转化生长因子 β（TGF-β）信号通路）影响人肿瘤细胞的上皮-间充质转化（EMT），对癌症的发展至关重要。此外，最近的研究已经确定了 microRNA（miRNA）传递系统载体，以改善 miR-375 在体内向特定部位的运输。在这里，我们讨论了 miR-375 在不同类型癌症中的作用以及分子机制，并分析了 miR-375 作为分子生物标志物和治疗靶点的潜力，以提高癌症临床诊断的效率。
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