Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
HIV Med. 2022 Feb;23(2):111-120. doi: 10.1111/hiv.13164. Epub 2021 Sep 7.
As the life expectancy of people living with HIV (PLWH) approaches that of the general population, the burden of comorbidities such as cardiovascular disease (CVD) is increasing. Regardless of HIV status, about 50% of CVD deaths worldwide occur in Asia, and Asian PLWH have a high prevalence of conventional CVD risk factors, such as smoking, dyslipidaemia, hypertension and insulin resistance or diabetes. As well as conventional CVD risk factors, PLWH have HIV-specific risk factors such as chronic inflammation, immune activation and endothelial damage, as well as risk factors related to antiretroviral therapy. This review describes the current knowledge on the epidemiology and risk factors of CVD in Asian PLWH and provides an Asian perspective on the recommendations for managing CVD risk in PLWH.
随着感染艾滋病毒（HIV）人群的预期寿命接近普通人群，心血管疾病（CVD）等合并症的负担正在增加。无论 HIV 状况如何，全球约有 50%的 CVD 死亡发生在亚洲，亚洲 HIV 感染者普遍存在传统 CVD 风险因素，如吸烟、血脂异常、高血压和胰岛素抵抗或糖尿病。除了传统的 CVD 风险因素外，HIV 感染者还具有 HIV 特异性风险因素，如慢性炎症、免疫激活和内皮损伤，以及与抗逆转录病毒治疗相关的风险因素。本文综述了亚洲 HIV 感染者 CVD 的流行病学和危险因素的现有知识，并就 HIV 感染者 CVD 风险管理的建议提供了亚洲视角。
