Centre for Pathogen Host Research, UCD School of Medicine, University College Dublin , Dublin, Ireland.
Department of Infectious Diseases, St. Vincent's University Hospital , Dublin, Ireland.
Expert Rev Anti Infect Ther. 2020 Jul;18(7):677-688. doi: 10.1080/14787210.2020.1757430. Epub 2020 May 20.
Cardiovascular disease (CVD) is one of the leading causes of mortality in virally suppressed people living with HIV (PLWH) and with an aging population, is likely to become one of the leading challenges in maintaining good health outcomes in HIV infection. However, factors driving the risk of CVD in PLWH are multiple and may be different from those of the general population, raising challenges to predicting and managing CVD risk in this population.
In this review, we examine the relevant data regarding CVD in HIV infection including CVD prevalence, pathogenesis, and other contributing factors. We review the data regarding CVD risk prediction in PLWH and summarize factors, both general and HIV specific, that may influence CVD risk in this population. And finally, we discuss appropriate management of CVD risk in PLWH and explore potential therapeutic pathways which may mitigate CVD risk in the future in this population.
Following a comprehensive review of CVD risk in PLWH, we give our opinion on the primary issues in risk prediction and management of CVD in HIV infected individuals and discuss the future direction of CVD management in this population.
心血管疾病（CVD）是抑制病毒的艾滋病毒感染者（PLWH）和人口老龄化导致的主要死亡原因之一，可能成为维持艾滋病毒感染人群良好健康结果的主要挑战之一。然而，导致 PLWH 患 CVD 的因素是多方面的，可能与普通人群不同，这给预测和管理该人群的 CVD 风险带来了挑战。
在这篇综述中，我们检查了包括 CVD 流行率、发病机制和其他促成因素在内的与 HIV 感染相关的 CVD 相关数据。我们回顾了 PLWH 中 CVD 风险预测的数据，并总结了可能影响该人群 CVD 风险的一般因素和 HIV 特异性因素。最后，我们讨论了 PLWH 中 CVD 风险的适当管理，并探讨了未来可能减轻该人群 CVD 风险的潜在治疗途径。
在全面审查了 PLWH 的 CVD 风险之后，我们对 HIV 感染者 CVD 风险预测和管理的主要问题提出了意见，并讨论了该人群 CVD 管理的未来方向。
