Ueda K, Yamazaki S, Saegusa J, Someya S
Jpn J Exp Med. 1977 Dec;47(6):467-74.
Following i.v. infection with 2.3 to 2 X 10(6) viable organisms of Mycobacterium bovis strain Ravenel, congentitally athymic nude (nu/nu) mice of BALB/c background died earlier than their heterozygous (nu/+) counterparts, showing necrotic nodules in the heart and kidney with the involvement of liver and spleen. Pulmonary lesions in nu/nu mice, however, were less severe than those of dead nu/+ mice. In the reticuloendothelial organs of nu/nu mice, macrophages loaded numerous acid fast bacilli were transiently proliferated and later, necrotic-exudative lesions were produced without epithelioid granuloma formation, while necrotic lesions appeared at very early stage of infection in the other organs as well as adipose tissues. After thymocyte-reconstitution nu/nu mice were capable of developing epithelioid granulomas as seen in nu/+ mice, though having more numerous bacilli in granulomas than those of nu/+.
用2.3至2×10⁶个牛分枝杆菌拉韦内尔菌株的活菌体进行静脉感染后，BALB/c背景的先天性无胸腺裸鼠（nu/nu）比其杂合子（nu/+）对应物死亡更早，心脏和肾脏出现坏死结节，并累及肝脏和脾脏。然而，nu/nu小鼠的肺部病变不如死亡的nu/+小鼠严重。在nu/nu小鼠的网状内皮器官中，负载大量抗酸杆菌的巨噬细胞短暂增殖，随后产生坏死性渗出性病变，无上皮样肉芽肿形成，而在感染的早期，其他器官以及脂肪组织也出现坏死病变。胸腺细胞重建后，nu/nu小鼠能够像nu/+小鼠一样形成上皮样肉芽肿，尽管肉芽肿中的杆菌比nu/+小鼠更多。
