COVID-19 对多发性骨髓瘤的诊断和治疗的影响：来自加拿大中心的经验。

Impact of COVID-19 on the Diagnosis and Management of Multiple Myeloma: Experience from a Canadian Center.

机构信息

Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, Alberta; Charbonneau Cancer Research Institute, Calgary, Alberta, Canada.

Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, Alberta, Canada.

出版信息

Rev Invest Clin. 2022 Jan 3;74(1):16-22. doi: 10.24875/RIC.21000347.

DOI:10.24875/RIC.21000347

PMID:34495948

Abstract

BACKGROUND

The impact of coronavirus disease-19 on the management of multiple myeloma (MM) has been recognized. However, the real effect on clinical outcomes remains poorly understood.

OBJECTIVE

We describe a local experience of the management of MM patients and report their outcomes during the current pandemic.

METHODS

All consecutive symptomatic MM patients seen at our center since 03/20 were evaluated.

RESULTS

A cohort of 156 patients diagnosed from 01/19 to 12/20 was analyzed to interrogate differences in presentation patterns. A total of 553 MM patients were seen and/or treated at Tom Baker Cancer Center in the year of 2020. From those, 47.1% (n = 261) were tested for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Sixteen patients tested positive and data are presented. In addition, a decrease of 21.7% in the rate of new smoldering MM/MM diagnosis was observed in 2020 as compared to 2019. Further, an increase in deaths was also observed in 2020.

CONCLUSIONS

Our study confirms an increase lethality for MM patients infected with SARS-CoV-2. A balance between safety and need for cancer control should be emphasized.

摘要

背景

人们已经认识到 2019 冠状病毒病（COVID-19）对多发性骨髓瘤（MM）管理的影响。然而，其对临床结局的实际影响仍知之甚少。

目的

我们描述了当地对 MM 患者管理的经验，并报告了在当前大流行期间他们的结局。

方法

评估了自 2020 年 3 月以来在我们中心就诊的所有有症状的 MM 患者。

结果

分析了从 2019 年 1 月至 2020 年 12 月诊断的 156 例患者队列，以探究临床表现模式的差异。2020 年，汤姆贝克癌症中心共诊治了 553 例 MM 患者。其中，47.1%（n=261）接受了严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）检测。16 例患者检测结果为阳性，数据已列出。此外，与 2019 年相比，2020 年新发性冒烟型 MM/MM 诊断率下降了 21.7%。此外，2020 年的死亡率也有所上升。