Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica., Hospital de Clínicas "José de San Martín", Buenos Aires, Argentina.
Universidad de Buenos Aires, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC), Buenos Aires, Argentina.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):8317-8326. doi: 10.1080/14767058.2021.1973994. Epub 2021 Sep 8.
During pregnancy metabolic disorders that affect differently the fetus, are known. These could be early or late disorders.
To analyze different biochemical parameters in umbilical cord blood (UCB) of healthy and pathological newborns from mothers with metabolic disorders.
Samples from UCB (121) were analyzed of newborn from mothers with metabolic disorders who attended at Obstetrics Division. Patients were consecutive, prospective and transversally studied. Newborn were classified as healthy ( = 65) and pathological ( = 56). The maternal metabolic disorders were gestational or non-gestational diabetes, glucose intolerance, insulin resistance and/or obesity).The disorders of the pathological newborns were intrauterine growth restriction (IUGR) and/or fetal distress. Glucose (Glu), urea, creatinine, uric acid (UA), total bilirubin (TB), total proteins (TP), albumin (Alb), transaminases (ALT/AST), alkaline-phosphatase (ALP), gammaglutamyltranspeptidase (GGT), creatinkinasa (CK), lactatedehydrogenase, amylase (amy), pseudocholinesterase, iron, calcium, phosphorus, magnesium (Mg), sodium, potassium, chlorine, cholesterol (Chol), HDL-Chol, LDL-Chol, triglycerides (TG), high sensitivity C reactive protein (hsCRP) were determined by recommended methods. T-Student's and Mann Withney tests were applied, < .05.
Pathological neonates (: 56) showed a significant decrease in maternal gestation weeks (GW) and in newborn weight (NW) with respect to healthy newborns (: 65) from mothers with metabolic disorders ( < .0001). Pathological neonates from mothers with metabolic pathologies (: 56) showed significant increases in Chol, TG, TB ( < .01), LDL-Chol, UA, Mg, hsCRP, ALP levels ( < .05) and significant decreases in TP, Alb ( < .0001) and Glu, ALT, CK, GGT, amy ( < .05) in UCB with respect to healthy newborns.
In pathological newborn, the decrease in GW and NW would be related to IUGR that accompany these metabolic disorders. The increases observed of the analyzed parameters would be related to cellular destruction associated to maternal pathology and decreases of the parameters to IUGR with hepatic immaturity.
在妊娠期间，会出现影响胎儿的代谢紊乱，这些紊乱可能是早期或晚期的。
分析代谢紊乱母亲的脐血（UCB）中不同的生化参数，这些母亲的新生儿为健康或病理。
对代谢紊乱母亲分娩的 UCB （121）样本进行分析。这些患者连续、前瞻性、横向研究。新生儿分为健康（ = 65）和病理（ = 56）。母亲的代谢紊乱包括妊娠期或非妊娠期糖尿病、葡萄糖不耐受、胰岛素抵抗和/或肥胖症。病理新生儿的紊乱包括宫内生长受限（IUGR）和/或胎儿窘迫。通过推荐的方法测定葡萄糖（Glu）、尿素、肌酐、尿酸（UA）、总胆红素（TB）、总蛋白（TP）、白蛋白（Alb）、转氨酶（ALT/AST）、碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）、肌酸激酶（CK）、乳酸脱氢酶、淀粉酶（amy）、假性胆碱酯酶、铁、钙、磷、镁（Mg）、钠、钾、氯、胆固醇（Chol）、高密度脂蛋白胆固醇（HDL-Chol）、低密度脂蛋白胆固醇（LDL-Chol）、甘油三酯（TG）、高敏 C 反应蛋白（hsCRP）。应用 T 检验和曼-惠特尼检验， < 0.05。
病理新生儿（ = 56）与代谢紊乱母亲的健康新生儿（ = 65）相比，母亲的孕龄（GW）和新生儿体重（NW）显著降低（ < 0.0001）。代谢紊乱母亲的病理新生儿（ = 56）的 Chol、TG、TB（ < 0.01）、LDL-Chol、UA、Mg、hsCRP、ALP 水平显著升高（ < 0.05），TP、Alb 显著降低（ < 0.0001），Glu、ALT、CK、GGT、amy 显著降低（ < 0.05）。
在病理新生儿中，GW 和 NW 的降低与这些代谢紊乱相关的 IUGR 有关。观察到的参数增加与母体病理相关的细胞破坏有关，而参数的降低与伴有肝不成熟的 IUGR 有关。
