Pereira Sónia R, Hackett Becky, O'Driscoll David N, Sun Melody Cui, Downer Eric J
Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Neuronal Signal. 2021 Aug 24;5(3):NS20200080. doi: 10.1042/NS20200080. eCollection 2021 Sep.
Cannabidiol (CBD), one of the primary non-euphoric components in the L. plant, has undergone clinical development over the last number of years as a therapeutic for patients with Lennox-Gastaut syndrome and Dravet syndromes. This phytocannabinoid demonstrates functional and pharmacological diversity, and research data indicate that CBD is a comparable antioxidant to common antioxidants. This review gathers the latest knowledge regarding the impact of CBD on oxidative signalling, with focus on the proclivity of CBD to regulate antioxidants and control the production of reactive oxygen species. CBD is considered an attractive therapeutic agent for neuroimmune disorders, and a body of literature indicates that CBD can regulate redox function at multiple levels, with a range of downstream effects on cells and tissues. However, pro-oxidant capacity of CBD has also been reported, and hence caution must be applied when considering CBD from a therapeutic standpoint. Such pro- and antioxidant functions of CBD may be cell- and model-dependent and may also be influenced by CBD dose, the duration of CBD treatment and the underlying pathology.
大麻二酚（CBD）是大麻植物中主要的非致幻成分之一，在过去数年中已作为治疗伦诺克斯 - 加斯托综合征和德雷维特综合征患者的药物进行了临床开发。这种植物大麻素具有功能和药理多样性，研究数据表明，CBD是一种与常见抗氧化剂相当的抗氧化剂。本综述收集了有关CBD对氧化信号传导影响的最新知识，重点关注CBD调节抗氧化剂和控制活性氧产生的倾向。CBD被认为是治疗神经免疫疾病的一种有吸引力的治疗剂，大量文献表明，CBD可以在多个水平上调节氧化还原功能，对细胞和组织产生一系列下游影响。然而，也有报道称CBD具有促氧化能力，因此从治疗角度考虑CBD时必须谨慎。CBD的这种促氧化和抗氧化功能可能取决于细胞和模型，也可能受到CBD剂量、CBD治疗持续时间和潜在病理状况的影响。
