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从L.中分离出的大麻二酚可保护肠道屏障免受炎症和氧化应激的影响。

Cannabidiol Isolated From L. Protects Intestinal Barrier From Inflammation and Oxidative Stress.

作者信息

Cocetta Veronica, Governa Paolo, Borgonetti Vittoria, Tinazzi Mattia, Peron Gregorio, Catanzaro Daniela, Berretta Massimiliano, Biagi Marco, Manetti Fabrizio, Dall'Acqua Stefano, Montopoli Monica

机构信息

Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.

Department of Biotechnology, Chemistry and Pharmacy Department of Excellence 2018-2022, University of Siena, Siena, Italy.

出版信息

Front Pharmacol. 2021 Apr 28;12:641210. doi: 10.3389/fphar.2021.641210. eCollection 2021.

DOI:10.3389/fphar.2021.641210
PMID:33995048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8115937/
Abstract

The relevance and incidence of intestinal bowel diseases (IBD) have been increasing over the last 50 years and the current therapies are characterized by severe side effects, making essential the development of new strategies that combine efficacy and safety in the management of human IBD. Herbal products are highly considered in research aimed at discovering new approaches for IBD therapy and, among others, L. has been traditionally used for centuries as an analgesic and anti-inflammatory remedy also in different gastrointestinal disorders. This study aims to investigate the effects of different isolated compounds in an model of intestinal epithelium. The ability of treatments to modulate markers of intestinal dysfunctions was tested on Caco-2 intestinal cell monolayers. Our results, obtained by evaluation of ROS production, TEER and paracellular permeability measurements and tight junctions evaluation show Cannabidiol as the most promising compound against intestinal inflammatory condition. Cannabidiol is able to inhibit ROS production and restore epithelial permeability during inflammatory and oxidative stress conditions, suggesting its possible application as adjuvant in IBD management.

摘要

在过去50年中，肠道疾病（IBD）的相关性和发病率一直在上升，目前的治疗方法具有严重的副作用，因此开发在人类IBD管理中兼具疗效和安全性的新策略至关重要。草药产品在旨在发现IBD治疗新方法的研究中受到高度重视，其中，几个世纪以来，L. 也一直被传统地用作镇痛和抗炎药物，用于治疗不同的胃肠道疾病。本研究旨在研究不同分离化合物在肠道上皮模型中的作用。在Caco-2肠细胞单层上测试了治疗方法调节肠道功能障碍标志物的能力。我们通过评估ROS产生、TEER和细胞旁通透性测量以及紧密连接评估获得的结果表明，大麻二酚是对抗肠道炎症状况最有前景的化合物。大麻二酚能够在炎症和氧化应激条件下抑制ROS产生并恢复上皮通透性，表明其可能作为IBD管理的佐剂应用。

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