Fidecka S
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Pol J Pharmacol Pharm. 1987 Jul-Aug;39(4):353-60.
The effect of naloxone on the duration of sleep and on analgesia produced by ketamine, and on the development of tolerance and cross-tolerance with morphine to ketamine analgesic effects were investigated in mice. Ketamine produced a dose-dependent analgesia. Naloxone (4 mg/kg) significantly inhibited the analgesic effects of ketamine (40 mg/kg), but (given in a dose of 2 mg/kg) did not affect the duration of ketamine sleep. Chronic administration of ketamine (160 mg/kg twice daily for 7 days) resulted in a gradual shortening of ketamine sleep and in the development of tolerance to the analgesic action of ketamine. There also developed cross-tolerance between analgesic effects of morphine and ketamine. Ketamine (20 mg/kg) significantly inhibited symptoms of morphine abstinence produced in morphine-pelleted mice by naloxone administration or by pellet removal. The results suggest that at least some elements of the mechanism of action of ketamine and morphine may be common and related to the endogenous opioid system.
在小鼠中研究了纳洛酮对睡眠持续时间、氯胺酮产生的镇痛作用以及对氯胺酮镇痛作用的耐受性和与吗啡交叉耐受性发展的影响。氯胺酮产生剂量依赖性镇痛作用。纳洛酮（4毫克/千克）显著抑制氯胺酮（40毫克/千克）的镇痛作用，但（以2毫克/千克的剂量给药）不影响氯胺酮诱导的睡眠时间。慢性给予氯胺酮（160毫克/千克，每日两次，共7天）导致氯胺酮诱导的睡眠时间逐渐缩短，并对氯胺酮的镇痛作用产生耐受性。吗啡和氯胺酮的镇痛作用之间也产生了交叉耐受性。氯胺酮（20毫克/千克）显著抑制了通过给予纳洛酮或取出药丸在植入吗啡药丸的小鼠中产生的吗啡戒断症状。结果表明，氯胺酮和吗啡作用机制的至少某些要素可能是共同的，并且与内源性阿片系统有关。
