Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
School of Medical Sciences, Örebro University, Örebro, Sweden.
Alzheimers Dement. 2022 Jun;18(6):1155-1163. doi: 10.1002/alz.12462. Epub 2021 Sep 9.
We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer's disease (AD) and any dementia, neurodegenerative diseases, across generations.
A nationwide cohort born between 1980 and 2001 (index persons) were linked to their biological relatives (parents, grandparents, uncles/aunts) using Swedish national registers. We used Cox models to examine the cross-generation associations.
Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with ADHD had an increased risk of AD (hazard ratio 1.55, 95% confidence interval 1.26-1.89). The associations attenuated but remained elevated in grandparents and uncles/aunts. The association for early-onset AD was stronger than late-onset AD. Similar results were observed for any dementia.
ADHD is associated with AD and any dementia across generations. The associations attenuated with decreasing genetic relatedness, suggesting shared familial risk between ADHD and AD.
我们研究了注意力缺陷多动障碍（ADHD）这种神经发育障碍与阿尔茨海默病（AD）以及任何痴呆症、神经退行性疾病在多大程度上存在跨代关联。
利用瑞典全国性登记册，将 1980 年至 2001 年期间出生的全国性队列（索引个体）与其生物亲属（父母、祖父母、叔叔/阿姨）进行关联。我们使用 Cox 模型来研究跨代关联。
在 2132929 名索引个体的亲属中，有 3042 名父母、171732 名祖父母和 1369 名叔叔/阿姨被诊断为 AD。患有 ADHD 的个体的父母患 AD 的风险增加（风险比 1.55，95%置信区间 1.26-1.89）。这些关联在祖父母和叔叔/阿姨中减弱但仍然存在。早发性 AD 的关联强于晚发性 AD。任何痴呆症也有类似的结果。
ADHD 与 AD 和任何痴呆症在代际之间存在关联。随着遗传相关性的降低，关联减弱，这表明 ADHD 和 AD 之间存在共同的家族风险。
