Trinh Duong H, Huynh Oanh N, Nguyen Trung Q, Nguyen Hieu T, Nguyen Thao-Ly T, Pham Hung D, Nguyen Lien-Hoa D, Tran Phuong T
Faculty of Chemistry, VNUHCM-University of Science, Ho Chi Minh City, Vietnam.
Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2023 Jan;37(2):188-196. doi: 10.1080/14786419.2021.1960328. Epub 2021 Sep 9.
Two new polyisoprenylated benzophenones, planchoniones A () and B (), together with two known benzophenones () and six known xanthones (), were isolated from an ethyl acetate extract of the pericarp of Pierre. Their structures were established using spectroscopic methods, mainly 1D and 2D NMR. The four benzophenones were evaluated for their cytotoxicity against MCF-7 human breast cancer cells, and showed almost no activity. Meanwhile, compounds - were investigated for their inhibitory effects towards α-glucosidase, and γ-mangostin (5) exhibited the most remarkable effect with IC value of 15.3 ± 0.9 µM (compared with acarbose, IC = 224.9 ± 3.6 µM).
从光叶珙桐果皮的乙酸乙酯提取物中分离出两种新的聚异戊烯基化二苯甲酮，即光叶珙桐酮A（）和光叶珙桐酮B（），以及两种已知的二苯甲酮（）和六种已知的呫吨酮（）。通过光谱方法，主要是一维和二维核磁共振，确定了它们的结构。对这四种二苯甲酮进行了抗MCF - 7人乳腺癌细胞的细胞毒性评估，结果显示几乎没有活性。同时，研究了化合物 - 对α - 葡萄糖苷酶的抑制作用，γ - 山竹黄酮（5）表现出最显著的效果，IC值为15.3±0.9μM（与阿卡波糖相比，IC = 224.9±3.6μM）。
