Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.
Int J Gynaecol Obstet. 2021 Dec;155(3):450-454. doi: 10.1002/ijgo.13916. Epub 2021 Sep 16.
To evaluate fetal lung development using pulmonary artery Doppler in pregnant women who had recovered from COVID-19.
The prospective case-control study included 41 pregnant women who had recovered from COVID-19 and 43 healthy pregnant women (control group). All the women in the study group had been diagnosed with COVID-19 and had completed a quarantine period.
The demographic data of patients were similar in the groups (P > 0.05). Main pulmonary artery peak systolic velocity was higher and pulsatility indices were lower in pregnant women who recovered from COVID-19 compared to the controls (P < 0.001, P = 0.001). Acceleration time, ejection time, and acceleration/ejection time ratio (PATET) of the fetal MPA Doppler were significantly decreased in pregnant women who recovered from COVID-19 (P < 0.001, P = 0.036, and P = 0.002, respectively). The patients who had recovered from COVID-19 were divided into two groups: those treated with expectant management and those treated in hospital. The pulmonary artery acceleration time and PATET ratio were significantly lower in the group treated in the hospital (P = 0.023 and P = 0.045, respectively).
Detailed Doppler evaluations of the pulmonary artery may help in evaluating the fetal adverse effects of COVID-19 disease.
评估 COVID-19 康复孕妇的肺动脉多普勒超声评估胎儿肺发育情况。
前瞻性病例对照研究纳入 41 例 COVID-19 康复孕妇和 43 名健康孕妇（对照组）。所有研究组患者均确诊 COVID-19，完成隔离期。
两组患者的人口统计学数据相似（P>0.05）。与对照组相比，COVID-19 康复孕妇的主肺动脉峰值流速更高，搏动指数更低（P<0.001，P=0.001）。COVID-19 康复孕妇的胎儿主肺动脉多普勒加速时间、射血时间和加速/射血时间比（PATET）明显降低（P<0.001，P=0.036，P=0.002）。将 COVID-19 康复孕妇分为期待治疗组和住院治疗组。住院治疗组的肺动脉加速时间和 PATET 比值明显更低（P=0.023 和 P=0.045）。
详细的肺动脉多普勒评估可能有助于评估 COVID-19 疾病对胎儿的不良影响。
