Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, China.
Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, China.
Ecotoxicol Environ Saf. 2021 Dec 1;225:112700. doi: 10.1016/j.ecoenv.2021.112700. Epub 2021 Sep 6.
Forchlorfenuron is a widely used plant growth regulator. The uptake of forchlorfenuron and its major metabolites poses a potential risk for human health. However, little is known about the dissipation of forchlorfenuron and its major metabolites in agricultural food. In this study, the metabolite 4-hydroxyphenyl-forchlorfenuron was first identified in oriental melon, which exhibited the highest level of residues of 4.42-5.12 μg/kg on the 4-7th days after application. Forchlorfenuron was found to be dissipated rapidly in melon at the recommended application rates, with half-lives ranging from 1.20 to 1.33 days. The rate of dissipation of 4-hydroxyphenyl-forchlorfenuron was greater than that of metabolism from forchlorfenuron in the oriental melon. However, the other metabolite, 3-hydroxyphenyl-forchlorfenuron, was not detected in oriental melon. The risk assessment showed that the acute and chronic dietary exposure risks of forchlorfenuron in oriental melon were 0.0011-0.0037% and 0.06-0.12%, respectively, suggesting little health risk to Chinese consumers.
氯吡苯脲是一种被广泛使用的植物生长调节剂。氯吡苯脲及其主要代谢物的摄入对人类健康构成了潜在风险。然而，关于氯吡苯脲及其主要代谢物在农业食品中的消解情况知之甚少。在本研究中，首次在东方甜瓜中鉴定出代谢物 4-羟基苯-氯吡苯脲，其在施药后第 4-7 天的残留水平最高，为 4.42-5.12μg/kg。在推荐的施药剂量下，氯吡苯脲在甜瓜中的消解速度很快，半衰期在 1.20-1.33 天之间。4-羟基苯-氯吡苯脲的消解速度大于其在东方甜瓜中的代谢速度。然而，在东方甜瓜中未检测到另一种代谢物 3-羟基苯-氯吡苯脲。风险评估表明，东方甜瓜中氯吡苯脲的急性和慢性膳食暴露风险分别为 0.0011-0.0037%和 0.06-0.12%，这表明对中国消费者的健康风险很小。
