G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskayast. 1, 153045 Ivanovo, Russia.
Molecules. 2021 Aug 31;26(17):5292. doi: 10.3390/molecules26175292.
Molecular recognition of host/guest molecules represents the basis of many biological processes and phenomena. Enzymatic catalysis and inhibition, immunological response, reproduction of genetic information, biological regulatory functions, the effects of drugs, and ion transfer-all these processes include the stage of structure recognition during complexation. The goal of this review is to solicit and publish the latest advances in the design and sensing and binding abilities of porphyrin-based heterotopic receptors with well-defined geometries, the recognition ability of which is realized due to ionic, -bridge, charge transfer, hydrophobic, and hydrophilic interactions. The dissection of the considered low-energy processes at the molecular scale expands our capabilities in the development of effective systems for controlled recognition, selective delivery, and prolonged release of substrates of different natures (including drugs) to their sites of functioning.
分子对宿主/客体分子的识别是许多生物过程和现象的基础。酶催化和抑制、免疫反应、遗传信息的复制、生物调节功能、药物的作用以及离子转移——所有这些过程都包括在络合过程中结构识别的阶段。本综述的目的是征集和发表基于卟啉的异位受体的设计和传感及结合能力的最新进展，这些受体具有明确的几何形状，其识别能力是通过离子、桥、电荷转移、疏水和亲水相互作用来实现的。在分子尺度上对所考虑的低能量过程的剖析扩展了我们在开发有效系统方面的能力，这些系统用于对不同性质的底物（包括药物）进行控制识别、选择性传递和延长释放，使其到达作用部位。
