Vintanel-Moreno Clara, Martínez-González José María, Martínez-Rodríguez Natalia, Meniz-García Cristina, Leco-Berrocal Isabel
Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain.
J Clin Med. 2021 Aug 28;10(17):3875. doi: 10.3390/jcm10173875.
The clinical application of phentolamine mesylate (PM) as an anaesthetic reversal agent has been documented in the paediatric population and in conservative dentistry, but no studies have been conducted regarding dental implant surgery. A prospective randomised study was conducted on 60 patients eligible for mandibular implant treatment, randomly divided between a control group (CG) and an experimental group (EG), to whom PM was administered. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG ( < 0.05), except for systolic blood pressure (SBP), which increased slightly in EG, without posing a risk to patients. There were no differences in the occurrence of adverse effects between the two groups, except for greater difficulty in chewing and biting ( < 0.05) in CG and greater pain in the injection area ( = 0.043) in EG. Among EG patients, 83.3% reported that they would request PM again for future dental treatment. The use of PM offers an alternative to implant surgery, thereby increasing patients' quality of life without increasing the risks.
甲磺酸酚妥拉明（PM）作为麻醉苏醒剂在儿科人群和保守牙科中的临床应用已有文献记载，但尚未有关于牙种植手术的研究。对60例符合下颌种植治疗条件的患者进行了一项前瞻性随机研究，随机分为对照组（CG）和实验组（EG），后者给予PM。评估血流动力学变化、不良反应和患者满意度。CG和EG之间在血流动力学变化和术后疼痛方面未发现统计学显著差异（<0.05），但收缩压（SBP）除外，EG组收缩压略有升高，但对患者无风险。两组不良反应的发生率无差异，CG组咀嚼和咬合困难较大（<0.05），EG组注射部位疼痛较重（=0.043）除外。在EG组患者中，83.3%的患者表示他们会在未来的牙科治疗中再次要求使用PM。PM的使用为种植手术提供了一种替代方法，从而在不增加风险的情况下提高了患者的生活质量。
