School of Physical Education, Hangzhou Normal University, Hangzhou 311121, China.
Int J Environ Res Public Health. 2021 Aug 28;18(17):9078. doi: 10.3390/ijerph18179078.
Acute mountain sickness (AMS) is a common syndrome characterized by headache, dizziness, loss of appetite, weakness, and nausea. As a major public health issue, obesity has increased in high altitude urban residents and intermittent commuters to high altitudes. The present study investigated acute hypoxic exposure and hypoxic exercise on hypoxemia severity and AMS symptoms in a physically active obese man. In this case analysis, peripheral oxygen saturation (SpO) was used to evaluate hypoxemia, heart rate (HR) and blood pressure (BP) were used to reflect the function of autonomic nervous system (ANS), and Lake Louise scoring (LLS) was used to assess AMS. The results showed that acute hypoxic exposure led to severe hypoxemia (SpO = 72%) and tachycardia (HRrest = 97 bpm), and acute hypoxic exercise exacerbated severe hypoxemia (SpO = 59%) and ANS dysfunction (HRpeak = 167 bpm, SBP/DBP = 210/97 mmHg). At the end of the 6-h acute hypoxic exposure, the case developed severe AMS (LLS = 10) symptoms of headache, gastrointestinal distress, cyanosis, vomiting, poor appetite, and fatigue. The findings of the case study suggest that high physical activity level appears did not show a reliable protective effect against severe hypoxemia, ANS dysfunction, and severe AMS symptoms in acute hypoxia exposure and hypoxia exercise.
高山病（AMS）是一种常见的综合征，其特征为头痛、头晕、食欲不振、乏力和恶心。作为一个主要的公共卫生问题，肥胖在高海拔城市居民和间歇性高海拔通勤者中有所增加。本研究调查了身体活跃的肥胖男性在急性低氧暴露和低氧运动下的低氧血症严重程度和 AMS 症状。在本病例分析中，外周血氧饱和度（SpO）用于评估低氧血症，心率（HR）和血压（BP）用于反映自主神经系统（ANS）的功能，而路易斯湖评分（LLS）用于评估 AMS。结果表明，急性低氧暴露导致严重低氧血症（SpO = 72%）和心动过速（HRrest = 97 bpm），急性低氧运动加重严重低氧血症（SpO = 59%）和 ANS 功能障碍（HRpeak = 167 bpm，SBP/DBP = 210/97 mmHg）。在 6 小时急性低氧暴露结束时，该病例出现严重 AMS（LLS = 10）症状，包括头痛、胃肠道不适、发绀、呕吐、食欲不振和疲劳。病例研究的结果表明，高身体活动水平似乎并没有对急性低氧暴露和低氧运动中的严重低氧血症、ANS 功能障碍和严重 AMS 症状提供可靠的保护作用。
