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嗅觉诱导性性唤起导致的睡眠剥夺与束缚应激和手动性睡眠剥夺对叙利亚仓鼠视交叉上核和其他脑区神经递质和计时基因的影响——一项免疫组织化学研究。

Effects of Sleep Deprivation by Olfactorily Induced Sexual Arousal Compared to Immobilization Stress and Manual Sleep Deprivation on Neuromessengers and Time Keeping Genes in the Suprachiasmatic Nuclei and Other Cerebral Entities of Syrian Hamsters-An Immunohistochemical Study.

机构信息

Vitos Clincis of Forensic Psychiatry Eltville, 65346 Eltville, Germany.

Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, 20359 Hamburg, Germany.

出版信息

Int J Environ Res Public Health. 2021 Aug 31;18(17):9169. doi: 10.3390/ijerph18179169.

DOI:10.3390/ijerph18179169
PMID:34501759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8430648/
Abstract

We investigated the effects of sexual arousal induced by olfactory stimuli on the expression of neuromodulators, neurotransmitters and sexual steroid receptors in the suprachiasmatic nucleus (SCN, the circadian pacemaker of mammals) and other cerebral entities of Syrian hamsters () compared to manual sleep deprivation and immobilization stress. The hamsters kept under a 12:12 hours (h) light:dark cycle were deprived of sleep by sexual stimulation, gentle manual handling or immobilization stress for 1 h at the beginning of the light phase and subsequently sacrificed at zeitgeber time 01:00, respectively; for comparison, hamsters were manually sleep deprived for 6 or 20 h or sacrificed after completing a full sleep phase. As demonstrated by immunohistochemistry, apart from various alterations after manual sleep deprivation, sexual stimulation caused down-regulation of arginine-vasopressin (AVP), vasointestinal peptide (VIP), serotonin (5-HT), substance P (SP), and met-enkephalin (ME) in the SCN. Somatostatin (SOM) was diminished in the medial periventricular nucleus (MPVN). In contrast, an increase in AVP was observed in the PVN, that of oxytocin (OXY) in the supraoptic nucleus (SON), of tyrosine-hydroxylase (TH) in the infundibular nucleus (IN), and dopamine beta-hydroxylase (DBH) in the A7 neuron population of the brain stem (A7), respectively. Testosterone in plasma was increased. The results indicate that sexual arousal extensively influences the neuropeptide systems of the SCN, suggesting an involvement of the SCN in reproductive behavior.

摘要

我们研究了嗅觉刺激引起的性唤起对叙利亚仓鼠（）的视交叉上核（哺乳动物的昼夜节律起搏器）和其他大脑实体中神经调节剂、神经递质和性类固醇受体表达的影响，与手动睡眠剥夺和固定应激相比。保持在 12:12 小时（h）光照：黑暗周期中的仓鼠在光照期开始时通过性刺激、轻柔的手动处理或固定应激剥夺 1 小时睡眠，随后分别在 zeitgeber 时间 01:00 处死；为了比较，仓鼠手动睡眠剥夺 6 或 20 小时或完成完整睡眠阶段后处死。如免疫组织化学所示，除了手动睡眠剥夺后的各种改变外，性刺激导致视交叉上核中精氨酸加压素（AVP）、血管肠肽（VIP）、血清素（5-HT）、P 物质（SP）和甲硫氨酸脑啡肽（ME）的下调。在中脑室周围核（MPVN）中 somatostatin（SOM）减少。相比之下，在室旁核（PVN）中观察到 AVP 增加，在视上核（SON）中观察到催产素（OXY）增加，在下丘脑核（IN）中观察到酪氨酸羟化酶（TH）增加，在脑脑干 A7 神经元群（A7）中多巴胺β-羟化酶（DBH）分别增加。血浆中的睾丸激素增加。结果表明，性唤起广泛影响 SCN 的神经肽系统，表明 SCN 参与生殖行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/8aeb129811b5/ijerph-18-09169-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/8fed006b55fb/ijerph-18-09169-g0A13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/dc16e48c6bb9/ijerph-18-09169-g0A14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/5d831edfb435/ijerph-18-09169-g0A15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/8aeb129811b5/ijerph-18-09169-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/3c5baa264728/ijerph-18-09169-g0A7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/9a4e42ef21b2/ijerph-18-09169-g0A8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/0a91eea31be5/ijerph-18-09169-g0A9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/6c197d292d11/ijerph-18-09169-g0A10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/9f765603ed44/ijerph-18-09169-g0A11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/4edff9332fb9/ijerph-18-09169-g0A12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/8fed006b55fb/ijerph-18-09169-g0A13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/dc16e48c6bb9/ijerph-18-09169-g0A14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/5d831edfb435/ijerph-18-09169-g0A15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1805/8430648/8aeb129811b5/ijerph-18-09169-g001.jpg

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