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高增殖性 ICOSTregs 的分化受损与系统性红斑狼疮 (SLE) 患者疾病活动度从低到高的转变有关。

Impaired Differentiation of Highly Proliferative ICOS-Tregs Is Involved in the Transition from Low to High Disease Activity in Systemic Lupus Erythematosus (SLE) Patients.

机构信息

Department of Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.

Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.

出版信息

Int J Mol Sci. 2021 Aug 31;22(17):9501. doi: 10.3390/ijms22179501.

DOI:10.3390/ijms22179501
PMID:34502409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8430608/
Abstract

Dysregulations in the differentiation of CD4-regulatory-T-cells (Tregs) and CD4-responder-T-cells (Tresps) are involved in the development of active systemic lupus erythematosus (SLE). Three differentiation pathways of highly proliferative inducible costimulatory molecule (ICOS)- and less proliferative ICOS-CD45RACD31-recent-thymic-emigrant (RTE)-Tregs/Tresps via CD45RACD31-memory-Tregs/Tresps (CD31-memory-Tregs/Tresps), their direct proliferation via CD45RACD31-mature naïve (MN)-Tregs/Tresps, and the production and differentiation of resting MN-Tregs/Tresp into CD45RACD31-memory-Tregs/Tresps (CD31-memory-Tregs/Tresps) were examined in 115 healthy controls, 96 SLE remission patients, and 20 active disease patients using six color flow cytometric analysis. In healthy controls an appropriate sequence of these pathways ensured regular age-dependent differentiation. In SLE patients, an age-independently exaggerated differentiation was observed for all Treg/Tresp subsets, where the increased conversion of resting MN-Tregs/Tresps particularly guaranteed the significantly increased ratios of ICOS-Tregs/ICOS-Tresps and ICOS-Tregs/ICOS-Tresps during remission. Changes in the differentiation of resting ICOS-MN-Tresps and ICOS-MN-Tregs from conversion to proliferation caused a significant shift in the ratio of ICOS-Tregs/ICOS-Tresps in favor of ICOS-Tresps and a further increase in the ratio of ICOS-Tregs/ICOS-Tresps with active disease. The differentiation of ICOS-RTE-Tregs/Tresps seems to be crucial for keeping patients in remission, where their limited production of proliferating resting MN-Tregs may be responsible for the occurrence of active disease flares.

摘要

CD4 调节性 T 细胞（Tregs）和 CD4 应答性 T 细胞（Tresps）分化失调与活动性系统性红斑狼疮（SLE）的发展有关。通过 CD45RACD31-记忆-Tregs/Tresps（CD31-记忆-Tregs/Tresps）、CD45RACD31-成熟初始（MN）-Tregs/Tresps 的直接增殖以及静止 MN-Tregs/Tresp 向 CD45RACD31-记忆-Tregs/Tresps（CD31-记忆-Tregs/Tresps）的产生和分化，研究了 115 例健康对照、96 例 SLE 缓解患者和 20 例活动期患者的三种高增殖诱导共刺激分子（ICOS）和低增殖 ICOS-CD45RACD31-最近胸腺迁出（RTE）-Tregs/Tresps 的增殖性诱导分化途径。在健康对照组中，这些途径的适当顺序确保了正常的年龄依赖性分化。在 SLE 患者中，所有 Treg/Tresp 亚群均观察到年龄独立的过度分化，其中静止 MN-Tregs/Tresps 的转化率增加尤其保证了缓解期 ICOS-Tregs/ICOS-Tresps 和 ICOS-Tregs/ICOS-Tresps 比值的显著增加。静止 ICOS-MN-Tresps 和 ICOS-MN-Tregs 从转化为增殖的分化变化导致 ICOS-Tregs/ICOS-Tresps 比值向 ICOS-Tresps 倾斜，并随着疾病的活动进一步增加 ICOS-Tregs/ICOS-Tresps 比值。ICOS-RTE-Tregs/Tresps 的分化对于使患者保持缓解状态似乎至关重要，其增殖性静止 MN-Tregs 的有限产生可能是导致疾病活动发作的原因。

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本文引用的文献

1
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Curr Rheumatol Rep. 2021 Jan 29;23(2):12. doi: 10.1007/s11926-020-00978-5.
2
ICOS Tregs: A Functional Subset of Tregs in Immune Diseases.ICOS Tregs：免疫疾病中 Tregs 的一个功能亚群。
Front Immunol. 2020 Aug 28;11:2104. doi: 10.3389/fimmu.2020.02104. eCollection 2020.
3
Nuclear antigen-reactive CD4 T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys.
CD8 中枢记忆调节性 T 细胞分化耗竭参与肾移植排斥反应。
Front Immunol. 2025 Jan 24;16:1532086. doi: 10.3389/fimmu.2025.1532086. eCollection 2025.
4
Sex-specific differences in ICOS T helper cell differentiation in systemic lupus erythematosus patients with low disease activity.系统性红斑狼疮患者低疾病活动度时 ICOST 辅助性 T 细胞分化的性别差异。
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5
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Front Immunol. 2023 May 23;14:1164284. doi: 10.3389/fimmu.2023.1164284. eCollection 2023.
6
In or out of control: Modulating regulatory T cell homeostasis and function with immune checkpoint pathways.在控制之内还是之外：通过免疫检查点途径调节调节性 T 细胞的稳态和功能。
Front Immunol. 2022 Dec 15;13:1033705. doi: 10.3389/fimmu.2022.1033705. eCollection 2022.
7
Activation Markers on B and T Cells and Immune Checkpoints in Autoimmune Rheumatic Diseases.B 和 T 细胞激活标志物及自身免疫性风湿病中的免疫检查点。
Int J Mol Sci. 2022 Aug 4;23(15):8656. doi: 10.3390/ijms23158656.
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Kidney Int. 2021 Jan;99(1):238-246. doi: 10.1016/j.kint.2020.05.051. Epub 2020 Jun 24.
4
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6
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Cell Rep. 2020 Jan 7;30(1):112-123.e4. doi: 10.1016/j.celrep.2019.12.014.
7
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Autoimmunity. 2020 Feb;53(1):8-20. doi: 10.1080/08916934.2019.1693545. Epub 2019 Nov 27.
8
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10
The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target.白细胞介素-17 在系统性红斑狼疮中的作用及其作为治疗靶点的潜力。
Expert Rev Clin Immunol. 2019 Jun;15(6):629-637. doi: 10.1080/1744666X.2019.1593141. Epub 2019 Mar 25.