含不同杂环部分的地棘蛙素类似物的合成、DNA结合及抗病毒活性
Synthesis, DNA binding and antiviral activity of distamycin analogues containing different heterocyclic moieties.
作者信息
Arcamone F, Lazzari E, Menozzi M, Soranzo C, Verini M A
机构信息
Ricerca & Sviluppo Chimico, Farmitalia Carlo Erba, Milan, Italy.
出版信息
Anticancer Drug Des. 1986 Nov;1(3):235-44.
PMID:3450296
Abstract
A series of novel distamycin analogues possessing an additional benzene or heterocyclic ring have been synthesised and tested for selective DNA binding properties and antiviral activity. Inhibition of herpes virus in cell culture appears to be related to AT base pair specificity. Some of the new compounds are also more potent than the parent distamycin against Moloney sarcoma virus.
摘要
一系列带有额外苯环或杂环的新型双缩胍类似物已被合成，并针对其选择性DNA结合特性和抗病毒活性进行了测试。细胞培养中对疱疹病毒的抑制作用似乎与AT碱基对特异性有关。一些新化合物对莫洛尼氏肉瘤病毒的活性也比母体双缩胍更强。
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