Beardsmore C S, Wimpress S P, Thomson A H, Patel H R, Goodenough P, Simpson H
Department of Child Health, University of Leicester, Leicester Royal Infirmary, England, UK.
Bull Eur Physiopathol Respir. 1987 Sep-Oct;23(5):465-72.
Maximum voluntary coughing produces a flow-volume profile which incorporates the characteristics of a maximum expiratory flow-volume curve (MEFV). The cough flow-volume curve also has transient spikes of supramaximal flow, interspersed with portions of zero flow when the glottis is closed. The peak flow rates of the supramaximal flow transients during cough decrease in a linear fashion as lung volume goes down from total lung capacity to residual volume. Cough flow-volume curves have been recorded from forty-two subjects between the ages of 7 and 56 yr. The rate of change of cough peak flow shows a positive correlation with airway conductance measured plethysmographically in children. The ratio of forced expiratory flow to cough peak flow (the cough ratio) expresses the maximum expiratory flow rate during forced expiration as a proportion of that which can be achieved with a cough. The cough ratio declines during adult life, because although there is a fall in cough peak flow with age there is a proportionally greater fall in MEFV-equivalent flow. These investigations explore the information to be gained from cough flow-volume curves by examining the cough in a heterogeneous group of individuals.
最大自主咳嗽产生的流量-容积曲线包含了最大呼气流量-容积曲线（MEFV）的特征。咳嗽流量-容积曲线还具有瞬间的超最大流量峰值，声门关闭时会穿插出现零流量部分。咳嗽时超最大流量瞬间的峰值流速随着肺容积从肺总量降至残气量呈线性下降。已记录了42名年龄在7至56岁之间受试者的咳嗽流量-容积曲线。咳嗽峰值流量的变化率与通过体积描记法测量的儿童气道传导率呈正相关。用力呼气流量与咳嗽峰值流量之比（咳嗽比）表示用力呼气时的最大呼气流量率占咳嗽所能达到的最大呼气流量率的比例。咳嗽比在成年期会下降，因为尽管咳嗽峰值流量会随年龄下降，但MEFV等效流量下降的比例更大。这些研究通过检查一组异质性个体的咳嗽情况，探索从咳嗽流量-容积曲线中获取的信息。
