在 COVID-19 早期，C 反应蛋白升高预示着住院老年患者的生存状况更差。
Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients.
机构信息
School of Medicine, Health Faculty, University of Angers, Angers, France.
Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
出版信息
PLoS One. 2021 Sep 10;16(9):e0256931. doi: 10.1371/journal.pone.0256931. eCollection 2021.
BACKGROUND
The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients.
METHODS
Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for COVID-19. Potential confounders were age, sex, functional abilities, history of malignancies, hypertension, cardiomyopathy, albuminemia, number of acute health issues, use of antibiotics and respiratory treatments.
RESULTS
Ninety-five participants (mean±SD 88.0±5.5years; 49.5%women; mean CRP, 76.7±77.5mg/L; mean albuminemia, 32.9±6.0g/L) were included. Sixteen participants who did not survive at day 14 exhibited higher CRP level at baseline than the others (120.3±71.2 versus 67.9±76.1 mg/L, P = 0.002). There was no difference in albuminemia (P = 0.329). Plasma CRP level was directly associated with 14-day mortality (fully adjusted HR = 1.11, P = 0.025). The cut-off for CRP associated with 14-day mortality was set at 35mg/L (sensitivity = 0.88; specificity = 0.56). Those with CRP<35mg/L had longer survival time than the others (log-rank P<0.001).
CONCLUSIONS
Elevated CRP levels were associated with poorer 14-day survival in hospitalized geriatric COVID-19 patients.
背景
本队列研究旨在确定 COVID-19 早期 CRP 升高是否与老年患者的 14 天死亡率相关。
方法
评估因 COVID-19 住院的老年住院患者入院时的 CRP 水平和 14 天全因死亡率。潜在混杂因素包括年龄、性别、功能能力、恶性肿瘤史、高血压、心肌病、白蛋白血症、急性健康问题数量、抗生素和呼吸治疗的使用。
结果
共纳入 95 名参与者（平均±标准差 88.0±5.5 岁；49.5%为女性；平均 CRP 为 76.7±77.5mg/L；平均白蛋白血症为 32.9±6.0g/L）。14 天未存活的 16 名患者的 CRP 水平在基线时高于其余患者（120.3±71.2 与 67.9±76.1mg/L，P=0.002）。白蛋白血症无差异（P=0.329）。CRP 水平与 14 天死亡率直接相关（完全调整后的 HR=1.11，P=0.025）。与 14 天死亡率相关的 CRP 截断值设定为 35mg/L（灵敏度=0.88；特异性=0.56）。CRP<35mg/L 的患者比其余患者存活时间更长（对数秩 P<0.001）。
结论
在 COVID-19 住院的老年患者中，CRP 水平升高与 14 天生存率降低相关。
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