从乌苏里鼠尾草的地上部分中分离得到两种新的细胞毒乌苏烷三萜。
Two new cytotoxic ursane triterpenoids from the aerial parts of Salvia urmiensis Bunge.
机构信息
Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Cancer Immunology and Immunotherapy Group, Shiraz Institute for Cancer Research (ICR), School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Fitoterapia. 2021 Oct;154:105030. doi: 10.1016/j.fitote.2021.105030. Epub 2021 Sep 10.
Bioassay-guided fractionation of a dichloromethane extract of the aerial parts of Salvia urmiensis, an endemic plant species of Iran, led to the isolation of two new cytotoxic ursane triterpenoids, Salvurmin A and Salvurmin B. Their structures were elucidated by a combination of 1D and 2D NMR, HR-ESI-MS, IR and UV analysis. Cytotoxicity of the above-mentioned compounds were evaluated against two human cancerous cell lines (SW1116, MCF-7). IC values for Salvurmin A and Salvurmin B on colon cancer cell line (SW1116) were 41.6 ± 2.6 and 23.2 ± 0.4 μM respectively, in comparison to cisplatin as control positive. In addition, these two compounds exhibited cytotoxic activity on breast cancer cell line (MCF-7) with an IC of 54.2 ± 5.3 and 40.2 ± 3.1 μM for Salvurmin A and Salvurmin B, respectively. The cytotoxic activities of these two compounds present a promising potential for the future investigation on this endemic species of Salvia.
生物测定指导下对伊朗特有植物物种萨尔维亚乌尔米恩西亚的地上部分的二氯甲烷提取物进行分段，分离出两种新型细胞毒性乌苏烷三萜素，即萨尔瓦明 A 和萨尔瓦明 B。通过 1D 和 2D NMR、高分辨率电喷雾电离质谱（HR-ESI-MS）、IR 和 UV 分析相结合，确定了它们的结构。评估了上述化合物对两种人类癌细胞系（SW1116、MCF-7）的细胞毒性。萨尔瓦明 A 和萨尔瓦明 B 对结肠癌细胞系（SW1116）的 IC 值分别为 41.6 ± 2.6 和 23.2 ± 0.4 μM，与顺铂作为对照阳性相比。此外，这两种化合物对乳腺癌细胞系（MCF-7）也表现出细胞毒性活性，萨尔瓦明 A 和萨尔瓦明 B 的 IC 值分别为 54.2 ± 5.3 和 40.2 ± 3.1 μM。这两种化合物的细胞毒性活性为未来对这种萨尔维亚特有物种的研究提供了有希望的潜力。
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