Aquatic Biology Laboratory, Department of Zoology, Panjab University, Chandigarh, 160014, India.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Ferdinando Stagno d'Alcontres, S. Agata, Messina, Italy.
Environ Toxicol Pharmacol. 2021 Nov;88:103739. doi: 10.1016/j.etap.2021.103739. Epub 2021 Sep 9.
The kidney of Catla catla, chronically exposed to sub-lethal concentrations (0.24 μg/L and 0.41 μg/L) of cypermethrin revealed a significant elevation in the activity of antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST) and reduced glutathione (GSH) after 15 days, followed by a decline of up to 45 days. Lipid peroxidation (LPO) remained elevated throughout the exposure duration. Histology presented proliferated haematopoietic tissue, tubular and glomerular degeneration. The maximum increase in the mean degree of tissue change (DTC) was observed on the 45th day of treatment. Ultra-structure study depicted cytoplasmic vacuolation, fragmented RER, the proliferation of lysosomes, mitochondrial degeneration, and degenerative changes in the epithelial lining of renal tubules. Principal component analysis (PCA) of various biomarkers generated two components PCI (SOD, GST, GSH, LPO and DTC) and PCII (CAT). These findings suggest that long term exposure to cypermethrin can lead to various pathological alterations in the fish kidney which in turn might interfere with normal renal excretory mechanism.
长期暴露于低浓度（0.24μg/L 和 0.41μg/L）氯菊酯的印度产鲤肾脏中，抗氧化剂超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽-S-转移酶（GST）和还原型谷胱甘肽（GSH）的活性在 15 天后显著升高，随后在 45 天内下降。脂质过氧化（LPO）在整个暴露期间保持升高。组织学表现为造血组织增生、管状和肾小球变性。在治疗的第 45 天观察到组织变化平均程度（DTC）的最大增加。超微结构研究显示细胞质空泡化、内质网碎片化、溶酶体增殖、线粒体变性以及肾小管上皮 lining 的退行性变化。对各种生物标志物进行主成分分析（PCA）生成了两个成分 PCI（SOD、GST、GSH、LPO 和 DTC）和 PCII（CAT）。这些发现表明，长期暴露于氯菊酯会导致鱼类肾脏的各种病理改变，进而可能干扰正常的肾脏排泄机制。
