Cesk Slov Oftalmol. 2021 Spring;77(4):184-189. doi: 10.31348/2021/21.
To evaluate the effect of crosslinking (CXL) therapy on the change in the quality of visual acuity and the change in the topographic properties of the cornea - curvature, pachymetry, and change of astigmatism, coma abberation and CLMIaa (Cone Localisation and Magnitude Index).
A retrospective analytical study included 29 eyes of 24 patients who had progressed in the last 12 months and were suitable candidates for CXL surgery. The monitored parameters were the steepest, flatest and mean anterior instantaneous curvature (AICS, AICF, AICM) and the steepest, flatest and mean posterior instantaneous curvature (PICS, PICF, PICM) of the cornea, corneal thickness in the centre of the cornea (PACHC) and in the thinnest point of the cornea (PACHT), corneal astigmatism (ASTIG). coma (COMA), Cone Localization and Magnitude Index (CLMIaa) and uncorrected distance visual acuity (UDVA) with corrected distance visual acuity (CDVA). Data were analysed before surgery and 12 months after surgery. The AIC, COMA, CLMIaa and ASTIG parameters were analysed by paired t test. As the parameters of UDVA, CDVA, PIC and PACH did not meet the conditions of normal distribution, the Wilcoxon test was used to investigate the change in these parameters after CXL.
Twelve months after the procedure, we recorded an improvement in UDVA (p = 0.371) and CDVA (p = 0.825), an increase in PICS, PICF and PICM (p = 0.902; p = 0.87 and p = 0.555), a decrease in PACHCC (p = 0.294) and a decrease in CLMIaa (p = 0.113) that did not reach statistical significance. The decrease in PACHT (p = 0.027), decrease in COMA (p = 0.037) and decrease in anterior corneal curvature of AICS, AICF and AICM were statistically significant (p = 0.019; p = 0.010 and p = 0.005). The decrease in the value of astigmatism did not show statistical significance, as p = 0.297.
CXL corneal therapy has been shown to be an effective method to stabilize the cornea in progressive keratoconus, and to improve the higher order of coma. This contributes to the possible improvement of UDVA and CDVA.
评估交联（CXL）治疗对视力质量变化和角膜形貌变化——曲率、厚度和散光变化、彗差和 CLMIaa（锥体定位和大小指数）的影响。
一项回顾性分析研究纳入了 24 名患者的 29 只眼，这些患者在过去 12 个月中病情进展，适合进行 CXL 手术。监测的参数包括角膜最陡、最平瞬时曲率（AICS、AICF、AICM）和角膜最陡、最平瞬时曲率（PICS、PICF、PICM）、角膜中央厚度（PACHC）和角膜最薄点厚度（PACHT）、角膜散光（ASTIG）、彗差（COMA）、锥体定位和大小指数（CLMIaa）和未矫正距离视力（UDVA）与矫正距离视力（CDVA）。在术前和术后 12 个月分析数据。使用配对 t 检验分析 AIC、COMA、CLMIaa 和 ASTIG 参数。由于 UDVA、CDVA、PIC 和 PACH 参数不符合正态分布条件，因此使用 Wilcoxon 检验研究 CXL 后这些参数的变化。
术后 12 个月，我们记录到 UDVA（p=0.371）和 CDVA（p=0.825）改善，PICS、PICF 和 PICM 增加（p=0.902；p=0.87 和 p=0.555），PACHCC 减少（p=0.294）和 CLMIaa 减少（p=0.113），但无统计学意义。PACHT 减少（p=0.027）、COMA 减少（p=0.037）和 AICS、AICF 和 AICM 前角膜曲率减少具有统计学意义（p=0.019；p=0.010 和 p=0.005）。散光值的减少无统计学意义，p=0.297。
CXL 角膜治疗已被证明是一种稳定进行性圆锥角膜和改善高阶彗差的有效方法。这有助于提高 UDVA 和 CDVA。
