Cesk Slov Oftalmol. 2021 Spring;77(4):208-213. doi: 10.31348/2021/24.
We present the management of a severe case of recurrent periocular basal cell carcinoma, orbital invasion and exenteration.
The present case is of a recurrent basal cell carcinoma in a 84-year-old male presenting with non-healing lesion above right eyelid. A tumor excision was performed in May 2014. Histopathology revealed a basal cell carcinoma (dg. C44.1 ICD-10-CM) with positive margins. The re-excision of the lesion was performed. After two years, there was a local recurrence and orbital invasion. Indication for external curative radiation therapy. Plastic surgery of the upper eyelid. Orbital exenteration was indicated in January 2018. After another year, a recurrence of the tumor was once again noted. Histopathology revealed a basal cell carcinoma (dg. C44.1 (TNM 7, pMx, pNx, pTx)). The patient was indicated for external radiotherapy. There were no indications for biological treatment. After another year, a progression of the local finding was noted.
Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer of the periocular region. Primary treatment of basal cell carcinoma is surgical. Advanced lesions require extensive surgical interventions and other available treatment modalities. In some cases, mutilating surgery - exenteration of the orbit is inevitable. Despite a relatively small percentage of invasive diseases today, advanced stages may still occur; either as a result of the patient's late presentation, inadequate initial therapy aimed at maintaining critical periorbital structures, or due to high tumor aggression. The case report highlights necessity of radical resection of primary tumor with histological examination.
我们介绍了一例严重复发性眶周基底细胞癌、眼眶侵犯和眶内容剜除的治疗方法。
本例为 84 岁男性复发性基底细胞癌,表现为右眼上眼睑经久不愈的病变。2014 年 5 月行肿瘤切除术。组织病理学显示基底细胞癌(dg. C44.1 ICD-10-CM),切缘阳性。对病变进行了再次切除。两年后,局部复发并侵犯眼眶。行外部根治性放射治疗。行上眼睑整形术。2018 年 1 月行眼眶内容剜除术。又过了一年,肿瘤再次复发。组织病理学显示基底细胞癌(dg. C44.1(TNM 7,pMx,pNx,pTx))。患者行外部放射治疗。无生物治疗指征。又过了一年,局部发现肿瘤进展。
基底细胞癌(BCC)是眶周区域最常见的非黑色素瘤皮肤癌。基底细胞癌的主要治疗方法是手术。晚期病变需要广泛的手术干预和其他可用的治疗方法。在某些情况下,破坏性手术 - 眼眶内容剜除是不可避免的。尽管今天侵袭性疾病的比例相对较小,但仍可能出现晚期阶段;要么是因为患者就诊较晚,要么是因为最初旨在维持关键眶周结构的治疗不足,要么是因为肿瘤侵袭性较高。该病例报告强调了对原发性肿瘤进行彻底切除和组织学检查的必要性。