采用质量源于设计（QbD）方法，对邻苯二甲酸酯胶进行环保合成，实现纳米颗粒工程。
Eco-friendly synthesis of phthalate angico gum towards nanoparticles engineering using Quality by Design (QbD) approach.
机构信息
Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, PE, Brazil.
Research Center on Biodiversity and Biotechnology - BIOTEC, Federal University of Delta of Parnaiba, Parnaiba, PI, Brazil.
出版信息
Int J Biol Macromol. 2021 Nov 1;190:801-809. doi: 10.1016/j.ijbiomac.2021.09.012. Epub 2021 Sep 9.
We developed a new hydrophobic polymer based on angico gum (AG), and we produced new nanoparticles to expand the applications of natural polysaccharides in nanomedicine. Phthalate angico gum (PAG) was characterized by H NMR, FTIR, elementary analysis, solubility, XRD, and TG. PAG was a hydrophobic and semi-crystalline material, a relevant characteristic for drug delivery system applications. As a proof of concept, nevirapine (NVP) was selected for nanoparticles development. Plackett-Burman's experimental design was used to understand the influence of several factors in nanoparticles production. PAG proved to be a versatile material for producing nanoparticles with different characteristics. Optimized nanoparticles were produced using desirability parameters. NVP-loaded PAG nanoparticles formulation showed 202.1 nm of particle size, 0.23 of PDI, -17.1 of zeta potential, 69.8 of encapsulation efficiency, and promoted modified drug release for 8 h. Here we show that PAG presents as a promising biopolymer for drug delivery systems.
我们开发了一种基于茵蕉胶（AG）的新型疏水聚合物，并制备了新型纳米粒子，以拓展天然多糖在纳米医学中的应用。通过 H NMR、FTIR、元素分析、溶解度、XRD 和 TG 对邻苯二甲酸茵蕉胶（PAG）进行了表征。PAG 是一种疏水半结晶材料，这是药物传递系统应用的相关特征。作为概念验证，选择奈韦拉平（NVP）用于纳米粒子的开发。采用 Plackett-Burman 实验设计来了解生产过程中几个因素的影响。PAG 被证明是一种多功能材料，可用于生产具有不同特性的纳米粒子。使用期望参数生产了优化的纳米粒子。载有 NVP 的 PAG 纳米粒子制剂的粒径为 202.1nm，PDI 为 0.23，zeta 电位为-17.1，包封效率为 69.8，并促进了 8 小时的药物释放。这里我们表明 PAG 是一种有前途的药物传递系统用生物聚合物。
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