阿月浑子胶纳米颗粒稳定的 Pickering 乳液作为吲哚美辛载体。
Pickering emulsions stabilized with cashew gum nanoparticles as indomethacin carrier.
机构信息
Federal University of Ceará - UFC, Department of Analytical and Physical Chemistry, Campus do Pici, S/N, bloco 940, Fortaleza, Ceará, Brazil.
Federal University of Ceará - UFC, Department of Analytical and Physical Chemistry, Campus do Pici, S/N, bloco 940, Fortaleza, Ceará, Brazil.
出版信息
Int J Biol Macromol. 2019 Jul 1;132:534-540. doi: 10.1016/j.ijbiomac.2019.03.198. Epub 2019 Mar 26.
Polysaccharide nanoparticles with potential to stabilize Pickering emulsions have been recently object of many research. Acetylated cashew gum with different degrees of substitution has been used in this work, in the pursuit of obtaining stable Pickering emulsions. Acetylated cashew gum was characterized by infrared and nuclear resonance spectroscopy. Effects of cashew gum derivative acetyl content, droplet size, ionic strength, zeta potential on emulsion properties were investigated. As a proof of concept, indomethacin was encapsulated in droplets and its release profile determined. Data obtained revealed droplet sizes in the range 269-312 nm, with unimodal size distribution and zeta potential values from -46 Mv to -48 Mv. Encapsulation efficiencies were in the range 26-52%, a steady release profile reached in 3 h, releasing maximal 75% IND.
具有稳定 Pickering 乳液潜力的多糖纳米粒子最近成为许多研究的对象。本工作中使用了不同取代度的乙酰化腰果胶，以获得稳定的 Pickering 乳液。通过红外和核共振光谱对乙酰化腰果胶进行了表征。考察了腰果胶衍生物乙酰含量、液滴大小、离子强度、Zeta 电位对乳液性质的影响。作为概念验证，将吲哚美辛包封在液滴中并测定其释放曲线。实验结果显示液滴大小在 269-312nm 之间，具有单峰分布，Zeta 电位值在-46MV 到-48MV 之间。包封效率在 26-52%之间，在 3 小时内达到稳定释放，最大释放 75%的 IND。
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