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[移植肺病学]

[Transplantation pneumonology].

作者信息

Hoyer J

出版信息

MMW Munch Med Wochenschr. 1978 Feb 10;120(6):167-70.

PMID:345114
Abstract

The importance of the lung in graft surgery is essentially characterized by three points: infection in immunosuppression, transplantation lung and the transplant. The therapeutic reduction of endogenous defense increases the risk of infection considerably. Every hint of pulmonary infection in the patient with a transplant demands a thorough diagnostic investigation, even operative measures not being excluded in the course of clarification. The phenomenon of "transplantation lung" is probably caused by circulating antigen-antibody complexes. In lung transplantation, difficulties begin in obtaining a satisfactory organ, most donors with cerebral death cannot be considered. Immune-induced changes of the hemostasis system lead to microemboli and extravasation into the alveolar space. The risk of infection is greatest here, because the transplant is in constant communication with the outside world.

摘要

肺在移植手术中的重要性主要体现在三个方面

免疫抑制状态下的感染、移植肺以及移植本身。内源性防御功能的治疗性降低会显著增加感染风险。移植患者出现任何肺部感染迹象都需要进行全面的诊断性检查,在明确诊断过程中甚至不排除采取手术措施。“移植肺”现象可能是由循环中的抗原 - 抗体复合物引起的。在肺移植中,获取满意器官就开始面临困难,大多数脑死亡供体都不符合要求。免疫诱导的止血系统变化会导致微栓子形成并渗入肺泡腔。这里感染风险最大,因为移植器官与外界持续相通。

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