Shi Guomei, Chen Wenxiu, Gong Pengyu, Wang Meng, Zhou Junshan, Wang Xiaorong, Guo Minwang, Lu Jingye, Li Yan, Feng Hongxuan, Fu Xuetao, Zhou Rujuan, Xue Shouru
Department of Neurology, The Taixing People's Hospital, Taixing, Jiangsu, People's Republic of China.
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
J Inflamm Res. 2021 Sep 2;14:4361-4369. doi: 10.2147/JIR.S329612. eCollection 2021.
Stroke-associated pneumonia (SAP) is a standout complication after acute ischemic stroke (AIS), with a prevalence of 7-38%. The aim of this prospective study was to investigate the relationship between serum YKL-40 levels at admission and SAP.
Between August 2020 and February 2021, consecutive AIS patients from two centers were enrolled prospectively. Serum YKL-40 concentrations were measured via enzyme-linked immunosorbent assay. We performed logistic regression analyses to explore the relationship between YKL-40 and SAP. Receiver operating characteristic curve was also used to assess the predictive ability of YKL-40 in predicting SAP.
Ultimately, a total of 511 AIS patients were recruited. Multivariate logistic regression analysis showed that YKL-40 was independently related to SAP, whether as a continuous variable or as quartiles (=0.001). The area under curve of YKL-40 to predict SAP was 0.765. The optimal cutoff value of YKL-40 as a predictor of SAP was determined to be 206.4 ng/mL, where the sensitivity was 63.1% and the specificity was 82.0%.
Our study demonstrated that YKL-40 might be considered as a useful biomarker to predict SAP in AIS patients.
卒中相关性肺炎（SAP）是急性缺血性卒中（AIS）后一种突出的并发症，患病率为7%-38%。这项前瞻性研究的目的是探讨入院时血清YKL-40水平与SAP之间的关系。
在2020年8月至2021年2月期间，前瞻性纳入了来自两个中心的连续AIS患者。通过酶联免疫吸附测定法测量血清YKL-40浓度。我们进行了逻辑回归分析以探讨YKL-40与SAP之间的关系。还使用受试者工作特征曲线评估YKL-40预测SAP的能力。
最终，共招募了511例AIS患者。多变量逻辑回归分析表明，无论作为连续变量还是四分位数，YKL-40都与SAP独立相关（P=0.001）。YKL-40预测SAP的曲线下面积为0.765。YKL-40作为SAP预测指标的最佳截断值确定为206.4 ng/mL，此时灵敏度为63.1%，特异性为82.0%。
我们的研究表明，YKL-40可能被视为预测AIS患者发生SAP的有用生物标志物。
