Ramsey J M, Pipoly S W
Eur J Appl Physiol Occup Physiol. 1979 Mar 1;40(4):227-33. doi: 10.1007/BF00421514.
Since increases of erythrocytic 2,3-diphosphoglycerate (2,3-DPG) have been shown to enhance the release of oxygen from hemoglobin, experiments were designed to evaluate the response of 2,3-DPG to two different work-loads in 13 fasted human subjects. No signficant mean change in 2.3-DPG was found following 16 min of strenuous exercise on a bicycle ergometer, but when the subjects were subjected later to a greater workload for 20 min, there was a significant mean decrease in 2.3-DPG despite much individual variation. In addition, there was a significant positive correlation of 2.3-DPG reduction with increases in postexercise lactate, and a significant inverse correlation of oxygen consumption during exercise with postexercise lactate. The data suggest that the 2.3-DPG mechanism may not be compensating in exercise when the workload requires a preponderance of anaerobic metabolism promoting lactacidaemia.
由于红细胞内2,3 - 二磷酸甘油酸（2,3 - DPG）的增加已被证明能增强血红蛋白释放氧气的能力，因此设计了实验来评估13名空腹人类受试者的2,3 - DPG对两种不同工作量的反应。在自行车测力计上进行16分钟的剧烈运动后，未发现2,3 - DPG有显著的平均变化，但当受试者随后承受更大的工作量20分钟时，尽管个体差异很大，2,3 - DPG仍有显著的平均下降。此外，2,3 - DPG的降低与运动后乳酸的增加呈显著正相关，运动期间的耗氧量与运动后乳酸呈显著负相关。数据表明，当工作量需要大量无氧代谢促进乳酸血症时，2,3 - DPG机制在运动中可能无法起到代偿作用。
