盐酸羟考酮注射液与右美托咪定联合应用于胆囊病变患者 LC 麻醉的价值。

The Value of Combined Application of Oxycodone Hydrochloride Injection and Dexmedetomidine in Anesthesia for LC for Patients with Gallbladder Lesions.

机构信息

Department of Anaesthesiology, Second Affiliated Hospital of Xiamen Medical College, Fujian, Xiamen, China.

出版信息

J Healthc Eng. 2021 Sep 2;2021:1290650. doi: 10.1155/2021/1290650. eCollection 2021.

DOI:10.1155/2021/1290650

PMID:34512931

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8433014/

Abstract

OBJECTIVE

To analyze the effect of combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for laparoscopic cholecystectomy (LC) for patients with gallbladder lesions.

METHOD

93 patients with gallbladder lesions in our hospital were divided into 2 groups by the random number table method. 46 patients in the control group applied oxycodone hydrochloride injection in anesthesia, and 47 patients in the observation group applied oxycodone hydrochloride injection combined with dexmedetomidine in anesthesia.

RESULT

The T1 and T2 MAP levels in the observation group were lower than those in the control group ( < 0.05), and the difference between T3 and the control group was not significantly significant ( > 0.05). The T1 to T3 HR level in the observation group were lower than those in the control group ( < 0.05). The rate of excessive sedation (10.64%) and sedation inefficiency (12.77%) in the observation group was lower than that in the control group (28.26% and 30.43%), and the rate of satisfactory sedation (76.60%) was higher than that in the control group (41.30%) ( < 0.05). The postoperative awakening, tracheal tube removal, and first anal venting time were shorter in the observation group than in the control group ( < 0.05). The WHO scores of incisional pain at 6, 12, 24, and 48 hours after the operation were lower in the observation group than in the control group ( < 0.05). The T2 SOD level in the observation group was higher than that in the control group, and the ROS and MDA levels were lower than those in the control group ( < 0.05). The incidence of side effects of anesthetic in the observation group was 17.02%, which was not statistically different from the control group of 13.04% ( > 0.05).

CONCLUSION

The combined application of oxycodone hydrochloride injection and dexmedetomidine in anesthesia for LC for patients with gallbladder lesions can achieve better sedation and analgesia effect, accelerate postoperative awakening and recovery, and control oxidative stress and fluctuations in signs, without increasing anesthesia-related side effects.

摘要

目的

分析盐酸羟考酮注射液联合右美托咪定在胆囊病变患者腹腔镜胆囊切除术（LC）麻醉中的应用效果。

方法

选取我院胆囊病变患者 93 例，采用随机数字表法分为两组。对照组应用盐酸羟考酮注射液麻醉，观察组应用盐酸羟考酮注射液联合右美托咪定麻醉。

结果

观察组 T1、T2 时的 MAP 水平低于对照组（<0.05），T3 时与对照组差异无统计学意义（>0.05）；观察组 T1~T3 时的 HR 水平低于对照组（<0.05）。观察组过度镇静发生率（10.64%）和镇静无效发生率（12.77%）低于对照组（28.26%、30.43%），满意镇静发生率（76.60%）高于对照组（41.30%）（<0.05）。观察组术后苏醒时间、气管导管拔除时间、首次肛门排气时间短于对照组（<0.05）。观察组术后 6、12、24、48 h 的切口疼痛 WHO 评分低于对照组（<0.05）。观察组 T2 时的 SOD 水平高于对照组，ROS、MDA 水平低于对照组（<0.05）。观察组麻醉相关不良反应发生率为 17.02%，与对照组的 13.04%比较差异无统计学意义（>0.05）。