Department of Cardiology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1 Shangcheng Road, Yiwu, Zhejiang, China.
Electroencephalogram Room, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1 Shangcheng Road, Yiwu, Zhejiang, China.
J Healthc Eng. 2021 Aug 31;2021:6343677. doi: 10.1155/2021/6343677. eCollection 2021.
Cardiovascular disorders are one of the prominent causes of risks of mortality which accounts for high rate of the deaths at a global level. The risk of deadly myocardial infraction grows because of diabetes which even causes the development of heart failure.
The objective of this study was to understand and study the effect of glycyrrhizin on diabetes suffering rats with myocardial remodeling.
Streptozotocin was used for induction of diabetes, and 8-12 weeks later, the assessment of inflammation, fibrosis, and cardiac damage was evaluated. Histopathological analysis and immunohistochemistry was performed to analyze the effect in various groups. Western blotting was performed to understand the proteins expressed in diabetes, and also, their expression was noted in treatment groups.
There was a significant rise in TNF-, dense fibrosis, and collagen deposits in the STZ diabetes group. The effects of hyperglycemia were significantly improved in the glycyrrhizin-treated group. DAPI, BrDu, and caspase staining was also performed to understand apoptosis in tissues where the diabetic groups reported significant apoptosis, while the effects were significantly lower in the treated group.
All the observations indicate that glycyrrhizin has cardioprotective action in diabetic rats with myocardial remodeling and is due to the inhibition of the NF-B signaling pathway in the myocardial layer.
心血管疾病是导致全球死亡率较高的主要原因之一。糖尿病会增加致命性心肌梗死的风险，甚至导致心力衰竭。
本研究旨在了解和研究甘草酸对患有心肌重构的糖尿病大鼠的影响。
链脲佐菌素用于诱导糖尿病，8-12 周后，评估炎症、纤维化和心脏损伤。进行组织病理学分析和免疫组织化学分析，以研究各实验组的影响。进行 Western blot 分析以了解糖尿病中表达的蛋白质，同时注意治疗组中的表达。
在 STZ 糖尿病组中，TNF-、致密纤维化和胶原沉积显著增加。甘草酸治疗组显著改善了高血糖的影响。还进行了 DAPI、BrDu 和 caspase 染色以了解组织中的细胞凋亡，糖尿病组报告了显著的细胞凋亡，而治疗组的细胞凋亡明显降低。
所有观察结果表明，甘草酸对患有心肌重构的糖尿病大鼠具有心脏保护作用，这是由于心肌层中 NF-B 信号通路的抑制。
