Shen Ting, Liu Xiaoling, Zhuang Bo, Luo Qian, Jin Yishan, Li Guanghe, Jiang Yumei, Li Dejie, Chen Xianchuan, Tang Nuo, Xu Zhimin, Wang Lemin, Zheng Liang, Shen Yuqin
Department of Rehabilitation, Tongji Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, China.
Department of Geriatrics, Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Cardiovasc Med. 2021 Aug 26;8:705972. doi: 10.3389/fcvm.2021.705972. eCollection 2021.
Heart failure (HF) is one of the major causes of mortality worldwide, representing the terminal stage of several cardiovascular diseases. Exercise-based rehabilitation is a beneficial therapy for patients with chronic heart failure (CHF). However, there is a lack of specific guidance on clinical decision-making regarding optimal exercise intensity. It is necessary to optimize the clinical recommendations for HF exercises. We will evaluate the efficacy and safety of different aerobic exercise intensities in patients with heart failure with reduced ejection fraction (HFrEF): the HF-EI trial. This trial aims to assess the appropriate exercise intensity for patients with HFrEF. After a baseline assessment to determine the safety of exercise, 180 patients will be randomly assigned to supervised high-intensity exercise training (ET) group, supervised moderate intensity training (MIT) group, and control group at a ratio of 1:1:1. Patients randomly receiving high intensity training (HIT) undergo supervised ET (3 times/week, 30 min) for aerobic endurance at 70% peak oxygen consumption (peak VO) intensity for 12 weeks. The MIT patients will perform supervised aerobic ET (3 times/week, 35-42 min) at the anaerobic threshold (AT) intensity for 12 weeks. The control group will continue to maintain their daily activities and will not receive ET. During the baseline and follow-up period, physical examination, laboratory tests, cardiology diagnostic tests, cardiopulmonary exercise tests (CPET), 6-min walk distance (6MWD), scale scores, exercise steps, medications, and clinical events will be monitored. Throughout the research, sport bracelets and patient diaries will be used to monitor and record overall physical activity, training courses, and compliance. The HF-EI trial will evaluate the effects of different aerobic exercise intensities on peak VO, quality of life (QoL), and clinical events among patients with HFrEF. The findings of this trial will provide a basis for formulating exercise prescriptions for patients with HFrEF. http://www.chictr.org.cn/, identifier: ChiCTR2000036381.
心力衰竭（HF）是全球主要的死亡原因之一，代表了几种心血管疾病的终末期。基于运动的康复治疗对慢性心力衰竭（CHF）患者是一种有益的治疗方法。然而，在关于最佳运动强度的临床决策方面缺乏具体指导。有必要优化心力衰竭运动的临床建议。我们将评估不同有氧运动强度对射血分数降低的心力衰竭（HFrEF）患者的疗效和安全性：心力衰竭运动强度（HF-EI）试验。该试验旨在评估HFrEF患者的适宜运动强度。在进行基线评估以确定运动安全性后，180名患者将按1:1:1的比例随机分配至监督下的高强度运动训练（ET）组、监督下的中等强度训练（MIT）组和对照组。随机接受高强度训练（HIT）的患者以70%峰值耗氧量（峰值VO）强度进行监督下的ET（每周3次，每次30分钟）有氧耐力训练，持续12周。MIT组患者将以无氧阈（AT）强度进行监督下的有氧ET（每周3次，每次35 - 42分钟），持续12周。对照组将继续维持日常活动，不接受ET。在基线期和随访期，将监测体格检查、实验室检查、心脏病学诊断检查、心肺运动试验（CPET）、6分钟步行距离（6MWD）、量表评分、运动步数、药物使用情况及临床事件。在整个研究过程中，将使用运动手环和患者日记来监测和记录总体身体活动、训练课程及依从性。HF-EI试验将评估不同有氧运动强度对HFrEF患者峰值VO、生活质量（QoL）和临床事件的影响。该试验的结果将为制定HFrEF患者的运动处方提供依据。http://www.chictr.org.cn/，标识符：ChiCTR2000036381
