Department of Endocrinology and Diabetology, The Children's Memorial Health Institute, Warsaw, Poland.
Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
Pediatr Endocrinol Diabetes Metab. 2021;27(2):93-99. doi: 10.5114/pedm.2021.107163.
Numerous studies assessed the quality of life (QoL) of adult patients after Cushing's disease (CD) treatment. Available professional literature reveals that hypercortisolemia caused by CD may negatively impact the mood and social life. However, data on QoL of adult patients after CD treatment in childhood are scarce. Aim of the study: To study the QoL of adult patients treated for CD in childhood.
Eighteen out of 29 adult patients diagnosed in childhood with CD and/or treated at one center participated in a survey and completed WHO Quality of Life-BREF questionnaire. The influence of selected prognostic factors for the QoL has been analyzed. Patients data were compared with a control group with the same age and sex.
Participants (10 women and 8 men) were at the mean age of 28.93 years (19.75-40.33). No significant difference in the QoL was noted between analyzed patients and controls. Patients with hypopituitarism had lower results in domain 4 in comparison with patients without hypopituitarism (p = 0.31) and lower results in domain 2 in comparison with the control group (p = 0.045). Patients with a higher age at disease onset had lower results of the QoL in domain 1 (p = 0.031).
During long-term follow-up the QoL of patients after CD treatment in childhood is not significantly different wit QoL of healthy controls. Further studies are needed to expand the knowledge of factors that may contribute to the QoL in CD patients who were treated in childhood.
许多研究评估了库欣病（CD）治疗后成年患者的生活质量（QoL）。现有专业文献表明，CD 引起的皮质醇过多可能会对情绪和社交生活产生负面影响。然而，关于儿童时期接受 CD 治疗的成年患者 QoL 的数据却很少。研究目的：研究儿童时期接受 CD 治疗的成年患者的 QoL。
在一家中心诊断为 CD 的 29 名成年患者中有 18 名参与了一项调查并完成了 WHO 生活质量简表问卷。分析了对 QoL 有影响的选定预后因素。将患者数据与具有相同年龄和性别的对照组进行了比较。
参与者（10 名女性和 8 名男性）的平均年龄为 28.93 岁（19.75-40.33）。分析患者与对照组之间的 QoL 无显著差异。与无垂体功能减退症的患者相比，患有垂体功能减退症的患者在第四领域的评分较低（p=0.31），与对照组相比，在第二领域的评分较低（p=0.045）。疾病发病年龄较高的患者在第一领域的 QoL 评分较低（p=0.031）。
在长期随访中，儿童时期接受 CD 治疗的患者的 QoL 与健康对照组的 QoL 没有显著差异。需要进一步研究以扩大对儿童时期接受治疗的 CD 患者可能影响其 QoL 的因素的认识。
