Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland.
Nutr Cancer. 2022;74(6):2133-2141. doi: 10.1080/01635581.2021.1976806. Epub 2021 Sep 12.
Oral carcinoma is one of the most aggressive cancers, and despite the advances in the therapy, its mortality is still high. An attention in cancer treatment has focused on natural compounds due to their potential beneficial effects on human health. In this study, the effects of dietary supplement Fermented Wheat Germ Extract (FWGE) on oral tongue squamous cell carcinoma (OTSCC) cells were investigated using three cell lines (HSC-3, SAS, SCC-25) with variable aggressiveness. The cell viability was significantly decreased by the treatment with high concentration of FWGE in every cell line. Regarding migration and invasion, HSC-3 and SCC-25 cells were most sensitive to FWGE since their movement was significantly reduced with 5 and 10 mg/ml FWGE, while SAS was inhibited only with 10 mg/ml FWGE. Chemotherapeutic compounds (cisplatin and 5-fluorouracil) significantly reduced all OTSCC cells viability. Importantly, combination of these drugs with 10 mg/ml FWGE significantly decreased the cell viability compared to the treatment with the chemotherapeutics or FWGE alone. Based on these experiments, the use of FWGE seems to improve the anticancer effects on OTSCC cells. Further and clinical studies should be conducted to verify the positive effects of FWGE for OTSCC patients.
口腔癌是最具侵袭性的癌症之一，尽管治疗方法有所进步，但死亡率仍然很高。癌症治疗的一个关注点集中在天然化合物上，因为它们对人类健康可能有潜在的有益影响。在这项研究中，使用三种具有不同侵袭性的细胞系（HSC-3、SAS、SCC-25）研究了膳食补充剂发酵麦胚提取物（FWGE）对口腔舌鳞状细胞癌（OTSCC）细胞的影响。用高浓度 FWGE 处理后，每种细胞系的细胞活力均显著降低。关于迁移和侵袭，HSC-3 和 SCC-25 细胞对 FWGE 最敏感，因为用 5 和 10mg/ml FWGE 处理后，它们的运动明显减少，而 SAS 仅用 10mg/ml FWGE 抑制。化疗药物（顺铂和 5-氟尿嘧啶）显著降低了所有 OTSCC 细胞的活力。重要的是，与单独使用化疗药物或 FWGE 相比，用这些药物联合 10mg/ml FWGE 处理可显著降低细胞活力。基于这些实验，FWGE 的使用似乎可以提高对 OTSCC 细胞的抗癌作用。应该进行进一步的临床研究来验证 FWGE 对 OTSCC 患者的积极影响。
