University of Colorado, School of Medicine, Aurora, CO, USA.
Denver Public Health, Denver, CO, USA.
HIV Res Clin Pract. 2021 Aug;22(4):102-118. doi: 10.1080/25787489.2021.1975608. Epub 2021 Sep 12.
Understanding the relationship between HIV and SARS-CoV-2 has important public health implications.To summarize current research on COVID-19 among people with HIV (PWH) as published through 15 July 2021. We conducted a search of PubMed, Scopus, preprint databases (medRxiv, bioRxiv), and the references of publications found using key terms relevant to COVID-19 ('COVID-19' OR 'SARS-CoV-2' OR 'coronavirus') AND to HIV ('HIV' OR 'Human Immunodeficiency Virus' OR 'AIDS' OR 'Acquired Immunodeficiency Syndrome'). We summarized all articles that reported data or opinions on SARS-CoV-2 and HIV coinfection. Although many initial case series and cohort studies found no increased risk for SARS-CoV-2 infection or severe COVID-19 outcomes among PWH, recent studies have signaled an increased risk for severe COVID-19 disease progression even in the setting of well-controlled HIV. Whether this is due to the increased prevalence of comorbidities in PWH and other social determinants of health is unknown. These conflicting findings highlight the continued need for COVID-19 related research among PWH that addresses COVID-19 disease course as well as exacerbation of existing comorbidities already disproportionately represented among PWH.
了解 HIV 和 SARS-CoV-2 之间的关系对公共卫生具有重要意义。本研究旨在总结截至 2021 年 7 月 15 日发表的有关 HIV 感染者(PWH)中 COVID-19 的研究。我们检索了 PubMed、Scopus、预印本数据库(medRxiv、bioRxiv),并通过与 COVID-19(“COVID-19”或“SARS-CoV-2”或“冠状病毒”)和 HIV(“HIV”或“人类免疫缺陷病毒”或“AIDS”或“获得性免疫缺陷综合征”)相关的关键词,查阅了已发表文献的参考文献。我们总结了所有报告 SARS-CoV-2 和 HIV 合并感染数据或观点的文章。尽管许多最初的病例系列和队列研究发现 PWH 感染 SARS-CoV-2 或 COVID-19 严重结局的风险没有增加,但最近的研究表明,即使在 HIV 得到良好控制的情况下,PWH 也有发生严重 COVID-19 疾病进展的风险增加。这是否是由于 PWH 中合并症的患病率增加和其他健康的社会决定因素尚不清楚。这些相互矛盾的发现强调了需要在 PWH 中开展 COVID-19 相关研究,以解决 COVID-19 病程以及已经在 PWH 中不成比例地出现的现有合并症恶化问题。
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