McNaughton Daniel A, Macreadie Lauren K, Gale Philip A
School of Chemistry (F11), The University of Sydney, NSW 2006, Australia.
The University of Sydney Nano Institute (SydneyNano), The University of Sydney, NSW 2006, Australia.
Org Biomol Chem. 2021 Nov 18;19(44):9659-9674. doi: 10.1039/d1ob01545a.
The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven to be a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective compounds in the series, which facilitated strictly electroneutral transport.
事实证明，在亲脂性中心支架周围排列氢键供体是开发高效氯离子转运体的一种成功策略。在这项工作中，我们重新审视了一种吖啶酮1,9-双（硫代）脲基序，该基序此前已显示出作为阴离子传感器的潜力，并通过在周边苯基部分连接各种吸电子基团来扩展化合物系列。该系列中最有效的化合物实现了高水平的活性，促进了严格的电中性转运。
