Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 11221, Egypt.
General Organization for Veterinary Services, Giza, Egypt.
Parasitol Res. 2021 Nov;120(11):3883-3893. doi: 10.1007/s00436-021-07311-8. Epub 2021 Sep 13.
Parasitic gastroenteritis (PGE) is one of the most important parasitic diseases that causes economic losses and health problems in ruminants. PGE causes a drop in milk, meat, and wool production in addition to decreasing animal fertility and sometimes leading to animal death. Conventional anthelmintics used for animal treatment are expensive, especially for farmers in developing countries. Moreover, the concern of anthelmintic resistance to these synthetic drugs is rising. Therefore, this study aimed to evaluate the anthelmintic activity of plant extract pomegranate (Punica granatum L) peel extract (PPE) against PGE infestations among ruminants. A total of 120 ruminants of different species (20 cattle, 12 buffalos, 68 sheep, and 20 goats) were examined for PGE eggs in their fecal samples. The animals under experiment were divided into four groups: the first group (negative control) was not given any drugs, the second group was given ivermectin (0.5 ml/25 kg bwt) (positive control 1), the third group was given albendazole (2.5 mg active principle/kg bwt) (positive control 2), and the fourth group was given PPE (200 mg/kg bwt). Fecal egg count (FEC) was performed on day 0 prior to the 1st dose of treatment. On day 15, an additional treatment (with the same doses) was administered and FEC was performed on days 7 and 21. Our results showed that on the 7th day of the experiment, there was an increase in FEC in the negative control group by 5%, while in the second, third, and fourth groups, there was a decrease in FEC with 95%, 90%, and 85% respectively. On the 21st day (7 days from the second dose), there was an increase in FEC in the control group by a 10% and 100% reduction in FEC in both the second and third groups. While in the fourth group, there was a decrease in FEC by 97%. In conclusion, PPE could be used as a safe, cheap, and effective natural anthelmintic against PGE.
寄生虫性胃肠炎 (PGE) 是一种最重要的寄生虫病，它会导致反刍动物的经济损失和健康问题。PGE 除了降低动物的繁殖力外，还会导致牛奶、肉类和羊毛产量下降，有时甚至导致动物死亡。用于动物治疗的常规驱虫剂价格昂贵，特别是对于发展中国家的农民来说。此外，人们越来越担心这些合成药物的驱虫剂耐药性。因此，本研究旨在评估植物提取物石榴（Punica granatum L）皮提取物（PPE）对反刍动物 PGE 感染的驱虫活性。总共检查了 120 只不同物种的反刍动物（20 头牛、12 头水牛、68 只绵羊和 20 只山羊）的粪便样本中的 PGE 卵。实验动物分为四组：第一组（阴性对照）未给予任何药物，第二组给予伊维菌素（0.5 ml/25 kg bwt）（阳性对照 1），第三组给予阿苯达唑（2.5 mg 有效成分/ kg bwt）（阳性对照 2），第四组给予 PPE（200 mg/kg bwt）。在第 1 次剂量治疗前的第 0 天进行粪便卵计数（FEC）。第 15 天，给予额外的治疗（相同剂量），并在第 7 天和第 21 天进行 FEC。我们的结果表明，在实验的第 7 天，阴性对照组的 FEC 增加了 5%，而第二、三和四组的 FEC 分别减少了 95%、90%和 85%。在第 21 天（第二次剂量后 7 天），对照组的 FEC 增加了 10%，第二和第三组的 FEC 分别减少了 100%和 100%。而在第四组中，FEC 减少了 97%。总之，PPE 可以作为一种安全、廉价、有效的天然驱虫剂，用于治疗 PGE。
