Department of Honeybee, Silkworm and wildlife diseases, Razi vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Department of Animal Sciences, Kurdistan Agricultural and Natural Resources Research and Education Center, (AREEO), Sanandaj, Iran.
Parasitol Int. 2024 Dec;103:102940. doi: 10.1016/j.parint.2024.102940. Epub 2024 Jul 31.
The use of medicinal plants as a means of combating parasites is becoming increasingly popular due to general resistance to synthetic anthelmintics. Goats typically respond less well to anthelminthic treatments, which may increase their resistance to nematodes. For this purpose, the anthelmintic effect of Pelargonium quercetorum Agnew (P. quercetorum) extract was tested in an in vivo study against gastrointestinal parasites of goats. A total of 40 goats naturally infected with mixed gastrointestinal nematode species were divided into four groups: the first group was treated with albendazole (7.5 mg/kg), the second group received a single dose of closantel (7.5 mg/kg), the third group received plant extract (7.5 mg/kg), and the fourth group served as an untreated control. Fecal egg counts (FEC) were carried out on day 14, as well as day 0, which was prior to the first treatment dose. According to the results, maximum reduction in FEC percentage was observed in P. quercetorum treated group (63.41%). Furthermore, nematode parasites responded poorly to synthetic drugs, although there was a 4.72% and 45.54% decrease in FEC in the albendazole and closantel-treated groups, respectively. Although no significant difference was found between the treatment groups, the P. quercetorum treated group showed a significant reduction in fecal egg count after treatment. Based on findings, a P. quercetorum based anthelmintic could be a sustainable alternative to combat parasite infestation. Therefore, further studies are needed to determine the optimal dose rate and frequency of doses required for effective control of gastrointestinal parasites in goats.
由于对合成驱虫药的普遍耐药性，药用植物作为对抗寄生虫的手段越来越受欢迎。山羊通常对驱虫处理的反应较差，这可能会增加它们对线虫的抵抗力。为此，本研究在体内试验中测试了 Pelargonium quercetorum Agnew（P. quercetorum）提取物对山羊胃肠道寄生虫的驱虫效果。共有 40 只自然感染混合胃肠道线虫的山羊被分为四组：第一组用阿苯达唑（7.5mg/kg）治疗，第二组单次给予氯硝柳胺（7.5mg/kg），第三组给予植物提取物（7.5mg/kg），第四组作为未处理的对照组。在第 14 天和第一次治疗剂量前的第 0 天进行粪便虫卵计数（FEC）。结果表明，P. quercetorum 处理组的 FEC 百分比最大减少（63.41%）。此外，尽管阿苯达唑和氯硝柳胺处理组的 FEC 分别减少了 4.72%和 45.54%，但线虫寄生虫对合成药物的反应不佳。尽管治疗组之间没有发现显著差异，但 P. quercetorum 处理组在治疗后粪便卵计数显著减少。基于这些发现，以 P. quercetorum 为基础的驱虫药可能是对抗寄生虫感染的可持续替代方法。因此，需要进一步研究以确定有效控制山羊胃肠道寄生虫所需的最佳剂量率和剂量频率。
