Pascalon A, Bertrand M
Laboratoire de Pathologie de la Reproduction, Ecole Nationale Vétérinaire de Lyon, Charbonnières, France.
Ann Rech Vet. 1987;18(4):379-88.
The effects of different levels of food restriction on the fetal-embryo development have been tested in rats (Sprague Dawley) weighing 250 g. Experimental groups received 100 (control), 75, 50 or 25% of mean daily consumed food containing 17% of proteins, either from the coupling (Day 1) or from the nestling (Day 6) and till the sacrifice (Day 21). The weight of the mothers and the fetus is diminished in function of the degree and the duration of the food restriction. The study of the maternal growth shows an adaptation to the food restriction as well as the pregnancy anabolism. The last one is not observed in the females presenting an early embryonic mortality. The nestling is not affected in any of the groups and the embryonic mortality is only observed at the highest restricted level in 1/10 female restricted from Day 6 on and in 5/10 of the rats restricted from Day 1 on. In these last ones, the emaciation between Day 1 and Day 21 after hysterectomy is 37% and the growth of the surviving fetuses is only 40% of the controls. Embryonic mortality most often precocious (before the 10th Day) shows a phenomenon of "all or none" and touches the entire litter of the females concerned; the others maintain a normal pregnancy. The fetal growth seems privileged as compared with the maternal growth. These restrictions have neither influenced the sex ratio, nor induced any specific teratogenic effect: the delayed ossification seems to be expressed precociously on the 5th sternebra.
在体重250克的大鼠（斯普拉格-道利大鼠）身上测试了不同程度的食物限制对胚胎发育的影响。实验组从交配日（第1天）或育雏日（第6天）开始，直至处死日（第21天），分别给予平均每日消耗量的100%（对照组）、75%、50%或25%的食物，这些食物含有17%的蛋白质。母体和胎儿的体重随着食物限制的程度和持续时间而减轻。对母体生长的研究表明，母体对食物限制以及妊娠合成代谢具有适应性。在出现早期胚胎死亡的雌性大鼠中未观察到妊娠合成代谢。在任何一组中，幼崽均未受到影响，仅在从第6天开始限制饮食的1/10雌性大鼠以及从第1天开始限制饮食的5/10大鼠中，在最高限制水平观察到胚胎死亡。在后者中，子宫切除术后第1天至第21天的消瘦率为37%，存活胎儿的生长仅为对照组的40%。胚胎死亡大多早熟（在第10天之前），呈现“全或无”现象，并影响相关雌性大鼠的整个窝仔；其他大鼠维持正常妊娠。与母体生长相比，胎儿生长似乎更受青睐。这些限制既未影响性别比例，也未诱发任何特定的致畸效应：延迟骨化似乎在第5块胸骨上过早表现出来。
