Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anesthesiology and Critical Care, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mult Scler Relat Disord. 2021 Nov;56:103256. doi: 10.1016/j.msard.2021.103256. Epub 2021 Sep 6.
This systematic review and meta-analysis aims to evaluate efficacy of deep brain stimulation (DBS) in treating MS-related tremor.
We systematically searched PubMed, Web of Science, Embase, Scopus, Google Scholar, and gray literature using a search strategy including the MeSH and text words as (((Brain Stimulations) OR (Deep Brain Stimulations) OR (Deep Brain Stimulations) OR (Deep Brain Brain Stimulation) OR (Deep Electrical Stimulation of the Brain)) AND (Multiple Sclerosis OR Sclerosis, Multiple) OR Sclerosis, Disseminated) OR Disseminated Sclerosis) OR MS (Multiple Sclerosis)) OR Multiple Sclerosis, Acute Fulminating).
The literature search revealed 1663 articles, 1027 of which remained after removing duplicates. Seventeen articles, published between 1999-2018, were included for the meta-analysis, including overall 168 patients. Follow-up time ranged between 6-62 months. The pooled frequency of tremor improvement among the enrolled patients was 73%, (95% CI:64-83%) (I=84.1%, p<0.001). The pooled standardized mean difference (SMD) (after -before) was -2.9, (95% CI:-4.8, -0.98) (I=89.8%, p<0.001).
The results of this systematic review and meta-analysis demonstrate MS-related tremor improvement after DBS.
本系统评价和荟萃分析旨在评估深部脑刺激（DBS）治疗多发性硬化症相关震颤的疗效。
我们系统地检索了 PubMed、Web of Science、Embase、Scopus、Google Scholar 和灰色文献，使用包括 MeSH 和文本词的搜索策略，如（（脑刺激）或（深部脑刺激）或（深部脑刺激）或（深部脑电刺激）或（深部电刺激大脑））和（多发性硬化症或硬化症，多发性）或硬化症，播散性）或播散性硬化症）或 MS（多发性硬化症））或多发性硬化症，急性暴发性）。
文献检索显示有 1663 篇文章，去除重复后仍有 1027 篇。有 17 篇文章于 1999 年至 2018 年发表，纳入荟萃分析，共 168 例患者。随访时间为 6-62 个月。纳入患者的震颤改善总频率为 73%（95%CI：64-83%）（I=84.1%，p<0.001）。荟萃分析的标准化均数差（SMD）（后-前）为-2.9（95%CI：-4.8，-0.98）（I=89.8%，p<0.001）。
本系统评价和荟萃分析的结果表明，DBS 治疗多发性硬化症相关震颤可改善震颤。
