Freeman M L, Reznikov I, Barnes W E, Nemchausky B, Kaplan E
Nuclear Medicine Services, USVA Hines Hospital, Hines, Illinois 60141.
Am J Physiol Imaging. 1987;2(3):110-7.
Hepatocyte function was analyzed following the injection of 5 mCi of Tc-99m disofenin by the computer generation of three kinds of functional images designed to portray regional rates of hepatic uptake. Nineteen patients were analyzed, of whom eight had no overt liver disease, five had active hepatitis, five had cirrhosis, and one had acute cholecystitis. Functional images were graded according to lack of regional homogeneity of accumulation. Uptake kinetics were found to be significantly more homogeneous in normal subjects, becoming increasingly heterogeneous in hepatitis and cirrhosis patients, respectively. Thus functional imaging may provide a tool for the quantitative analysis of parenchymal disruption in liver disease.
通过计算机生成三种旨在描绘肝脏摄取区域速率的功能图像，分析了注射5毫居里的锝-99m二乙基亚氨二乙酸后的肝细胞功能。对19名患者进行了分析，其中8名无明显肝脏疾病，5名患有活动性肝炎，5名患有肝硬化，1名患有急性胆囊炎。根据放射性药物摄取的区域均匀性对功能图像进行分级。发现正常受试者的摄取动力学明显更均匀，而在肝炎和肝硬化患者中分别变得越来越不均匀。因此，功能成像可为肝脏疾病实质破坏的定量分析提供一种工具。
